2-[1-(3-Cyclohexylmethoxy-2,5-dimethoxy-4,6-dimethyl-phenyl)-meth-(E)-ylidene]-7-pyridin-3-yl-heptanoic acid

Base Information

Chemical Name:2-[1-(3-Cyclohexylmethoxy-2,5-dimethoxy-4,6-dimethyl-phenyl)-meth-(E)-ylidene]-7-pyridin-3-yl-heptanoic acid
CAS No.:144562-92-5
Molecular Formula:C₃₀H₄₁NO₅
Molecular Weight:495.659
Hs Code.:

Synonyms:2-[1-(3-Cyclohexylmethoxy-2,5-dimethoxy-4,6-dimethyl-phenyl)-meth-(E)-ylidene]-7-pyridin-3-yl-heptanoic acid

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Chemical Property of 2-[1-(3-Cyclohexylmethoxy-2,5-dimethoxy-4,6-dimethyl-phenyl)-meth-(E)-ylidene]-7-pyridin-3-yl-heptanoic acid

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Technology Process of 2-[1-(3-Cyclohexylmethoxy-2,5-dimethoxy-4,6-dimethyl-phenyl)-meth-(E)-ylidene]-7-pyridin-3-yl-heptanoic acid

There total 9 articles about 2-[1-(3-Cyclohexylmethoxy-2,5-dimethoxy-4,6-dimethyl-phenyl)-meth-(E)-ylidene]-7-pyridin-3-yl-heptanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 144562-76-5
2-[1-(3-Cyclohexylmethoxy-2,5-dimethoxy-4,6-dimethyl-phenyl)-meth-(E)-ylidene]-7-pyridin-3-yl-heptanoic acid ethyl ester

: 144562-92-5
2-[1-(3-Cyclohexylmethoxy-2,5-dimethoxy-4,6-dimethyl-phenyl)-meth-(E)-ylidene]-7-pyridin-3-yl-heptanoic acid

Guidance literature:: With sodium hydroxide; In ethanol; water; for 1h; Yield given; Heating;
DOI:10.1021/jm950725r

Reference yield:

: 5469-33-0
cyclohexylmethyl iodide

: 144562-92-5
2-[1-(3-Cyclohexylmethoxy-2,5-dimethoxy-4,6-dimethyl-phenyl)-meth-(E)-ylidene]-7-pyridin-3-yl-heptanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NaH / 1.) DMF, 15 min, 2.) DMF, RT, 3 h

2: 1.) TiCl₄ / 1.) CH₂Cl₂, 0 deg C, 15 min, 2.) CH₂Cl₂, RT, 2.5 h

3: 1.) NaH / 1.) DMF, RT, 1 h, 2.) DMF, 50 deg C, overnight

4: NaOH / ethanol; H₂O / 1 h / Heating

With sodium hydroxide; titanium tetrachloride; sodium hydride; In ethanol; water;
DOI:10.1021/jm950725r

Reference yield:

: 31404-86-1
2,4-dimethyl-3,6-dimethoxybenzaldehyde

: 144562-92-5
2-[1-(3-Cyclohexylmethoxy-2,5-dimethoxy-4,6-dimethyl-phenyl)-meth-(E)-ylidene]-7-pyridin-3-yl-heptanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) m-CPBA, 2.) sodium methoxide / 1.) CH₂Cl₂, reflux, 30 min, 2.) methanol, RT, 30 min

2: 1.) NaH / 1.) DMF, 15 min, 2.) DMF, RT, 3 h

3: 1.) TiCl₄ / 1.) CH₂Cl₂, 0 deg C, 15 min, 2.) CH₂Cl₂, RT, 2.5 h

4: 1.) NaH / 1.) DMF, RT, 1 h, 2.) DMF, 50 deg C, overnight

5: NaOH / ethanol; H₂O / 1 h / Heating

With sodium hydroxide; sodium methylate; titanium tetrachloride; sodium hydride; 3-chloro-benzenecarboperoxoic acid; In ethanol; water;
DOI:10.1021/jm950725r