dimethyl (4,4'-biphenyldiylbis(1H-imidazole-4,2-diyl((2S,5S)-5-methyl-2,1-pyrrolidinediyl)((1S)-1-((2R,4r,6S)-2,6-dimethyltetrahydro-2H-pyran-4-yl)-2-oxo-2,1-ethanediyl)))biscarbamate

Base Information

Chemical Name:dimethyl (4,4'-biphenyldiylbis(1H-imidazole-4,2-diyl((2S,5S)-5-methyl-2,1-pyrrolidinediyl)((1S)-1-((2R,4r,6S)-2,6-dimethyltetrahydro-2H-pyran-4-yl)-2-oxo-2,1-ethanediyl)))biscarbamate
CAS No.:1393537-49-9
Molecular Formula:C₅₀H₆₆N₈O₈
Molecular Weight:907.123
Hs Code.:

dimethyl (4,4'-biphenyldiylbis(1H-imidazole-4,2-diyl((2S,5S)-5-methyl-2,1-pyrrolidinediyl)((1S)-1-((2R,4r,6S)-2,6-dimethyltetrahydro-2H-pyran-4-yl)-2-oxo-2,1-ethanediyl)))biscarbamate

Synonyms:dimethyl (4,4'-biphenyldiylbis(1H-imidazole-4,2-diyl((2S,5S)-5-methyl-2,1-pyrrolidinediyl)((1S)-1-((2R,4r,6S)-2,6-dimethyltetrahydro-2H-pyran-4-yl)-2-oxo-2,1-ethanediyl)))biscarbamate

Suppliers and Price of dimethyl (4,4'-biphenyldiylbis(1H-imidazole-4,2-diyl((2S,5S)-5-methyl-2,1-pyrrolidinediyl)((1S)-1-((2R,4r,6S)-2,6-dimethyltetrahydro-2H-pyran-4-yl)-2-oxo-2,1-ethanediyl)))biscarbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of dimethyl (4,4'-biphenyldiylbis(1H-imidazole-4,2-diyl((2S,5S)-5-methyl-2,1-pyrrolidinediyl)((1S)-1-((2R,4r,6S)-2,6-dimethyltetrahydro-2H-pyran-4-yl)-2-oxo-2,1-ethanediyl)))biscarbamate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of dimethyl (4,4'-biphenyldiylbis(1H-imidazole-4,2-diyl((2S,5S)-5-methyl-2,1-pyrrolidinediyl)((1S)-1-((2R,4r,6S)-2,6-dimethyltetrahydro-2H-pyran-4-yl)-2-oxo-2,1-ethanediyl)))biscarbamate

There total 11 articles about dimethyl (4,4'-biphenyldiylbis(1H-imidazole-4,2-diyl((2S,5S)-5-methyl-2,1-pyrrolidinediyl)((1S)-1-((2R,4r,6S)-2,6-dimethyltetrahydro-2H-pyran-4-yl)-2-oxo-2,1-ethanediyl)))biscarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1306729-84-9
(S)-2-((2R,4r,6S)-2,6-dimethyltetrahydro-2H-pyran-4-yl)-2-((methoxycarbonyl)amino)acetic acid

: C₂₈H₃₂N₆*4ClH

: 1393537-49-9
dimethyl (4,4'-biphenyldiylbis(1H-imidazole-4,2-diyl((2S,5S)-5-methyl-2,1-pyrrolidinediyl)((1S)-1-((2R,4r,6S)-2,6-dimethyltetrahydro-2H-pyran-4-yl)-2-oxo-2,1-ethanediyl)))biscarbamate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

Reference yield:

: 1004-36-0
2,6-dimethylpyrone

: 1393537-49-9
dimethyl (4,4'-biphenyldiylbis(1H-imidazole-4,2-diyl((2S,5S)-5-methyl-2,1-pyrrolidinediyl)((1S)-1-((2R,4r,6S)-2,6-dimethyltetrahydro-2H-pyran-4-yl)-2-oxo-2,1-ethanediyl)))biscarbamate

Guidance literature:: Multi-step reaction with 10 steps

1: hydrogen / palladium 10% on activated carbon / ethanol / 72 h / 20 °C / 3620.13 Torr

2: triphenylphosphine; diethylazodicarboxylate / benzene / 18 h / 20 °C

3: water; lithium hydroxide / tetrahydrofuran / 16 h / 20 °C

4: pyridine / dichloromethane / 84 h / 20 °C

5: lithium hexamethyldisilazane / toluene; tetrahydrofuran / 5 h / 20 - 100 °C

6: hydrogenchloride / water; tetrahydrofuran / 4 h / 20 °C

7: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C

8: Chiralpak AS-H column / n-heptane; ethanol / Resolution of racemate

9: hydrogen / palladium 10% on activated carbon / methanol / 15 h / 20 °C / 2068.65 Torr

10: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 3 h / 20 °C

With pyridine; hydrogenchloride; water; hydrogen; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; lithium hydroxide; lithium hexamethyldisilazane; diethylazodicarboxylate; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; n-heptane; dichloromethane; water; N,N-dimethyl-formamide; toluene; benzene;

Reference yield:

: 33747-09-0,41866-70-0,55473-43-3
(2R,4S,6S)-2,6-dimethyltetrahydro-2H-pyran-4-ol

: 1393537-49-9
dimethyl (4,4'-biphenyldiylbis(1H-imidazole-4,2-diyl((2S,5S)-5-methyl-2,1-pyrrolidinediyl)((1S)-1-((2R,4r,6S)-2,6-dimethyltetrahydro-2H-pyran-4-yl)-2-oxo-2,1-ethanediyl)))biscarbamate

Guidance literature:: Multi-step reaction with 9 steps

1: triphenylphosphine; diethylazodicarboxylate / benzene / 18 h / 20 °C

2: water; lithium hydroxide / tetrahydrofuran / 16 h / 20 °C

3: pyridine / dichloromethane / 84 h / 20 °C

4: lithium hexamethyldisilazane / toluene; tetrahydrofuran / 5 h / 20 - 100 °C

5: hydrogenchloride / water; tetrahydrofuran / 4 h / 20 °C

6: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C

7: Chiralpak AS-H column / n-heptane; ethanol / Resolution of racemate

8: hydrogen / palladium 10% on activated carbon / methanol / 15 h / 20 °C / 2068.65 Torr

9: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 3 h / 20 °C

With pyridine; hydrogenchloride; water; hydrogen; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; lithium hydroxide; lithium hexamethyldisilazane; diethylazodicarboxylate; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; n-heptane; dichloromethane; water; N,N-dimethyl-formamide; toluene; benzene;