6-Bromo-8-methyl[1,2,4]triazolo[1,5-a]pyridine

Base Information

• Chemical Name: 6-Bromo-8-methyl[1,2,4]triazolo[1,5-a]pyridine
• CAS No.: 899429-04-0
• Molecular Formula: C7H6 Br N3
• Molecular Weight: 212.04664
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID70468759
• Wikidata: Q82296144
• Mol file: 899429-04-0.mol

Synonyms:899429-04-0;6-Bromo-8-methyl[1,2,4]triazolo[1,5-a]pyridine;6-bromo-8-methyl-[1,2,4]triazolo[1,5-a]pyridine;MFCD09038166;[1,2,4]Triazolo[1,5-a]pyridine,6-bromo-8-methyl-;SCHEMBL19760991;DTXSID70468759;ZKB42904;AKOS015842405;SB74618;4-(Methylthio)-3-nitropyridin-2-amine;AS-66943;SY034828;CS-0147292;FT-0685666;F15631;EN300-1592164;A922494;J-518417;6-Bromo-8-methyl[1,2,4]triazolo[1,5-a]pyridine, AldrichCPR

Chemical Property of 6-Bromo-8-methyl[1,2,4]triazolo[1,5-a]pyridine

Chemical Property:

• Refractive Index: 1.715
• PSA: 30.19000
• Density: 1.767g/cm³
• LogP: 1.80020
• Storage Temp.: 2-8°C
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 210.97451
• Heavy Atom Count: 11
• Complexity: 153

Purity/Quality:

97% ^*data from raw suppliers

6-Bromo-8-methyl[1,2,4]triazolo[1,5-A]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=CN2C1=NC=N2)Br

Technology Process of 6-Bromo-8-methyl[1,2,4]triazolo[1,5-a]pyridine

There total 3 articles about 6-Bromo-8-methyl[1,2,4]triazolo[1,5-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-bromo-3-methyl-pyridin-2-ylamine (3430-21-5) + N,N-dimethyl-formamide dimethyl acetal (4637-24-5) → 6-bromo-8-methyl-[1,2,4]triazolo[1,5-a]pyridine (899429-04-0)

Guidance literature:

5-bromo-3-methyl-pyridin-2-ylamine; N,N-dimethyl-formamide dimethyl acetal; In N,N-dimethyl-formamide; at 130 ℃;

With pyridine; hydroxylamine-O-sulfonic acid; In methanol; at 20 ℃; Cooling with ice;

Reference yield:

N'-(5-bromo-3-methyl-pyridin-2-yl)-N,N-dimethyl-formamidine (883052-76-4) → 6-bromo-8-methyl-[1,2,4]triazolo[1,5-a]pyridine (899429-04-0)

Guidance literature:

With pyridine; hydroxylamine-O-sulfonic acid; In methanol; at 20 ℃;

DOI:10.1021/jm060015t

Reference yield:

5-bromo-3-methyl-pyridin-2-ylamine (3430-21-5) → 6-bromo-8-methyl-[1,2,4]triazolo[1,5-a]pyridine (899429-04-0)

Guidance literature:

Multi-step reaction with 2 steps

1: DMF / 12 h / 130 °C

2: pyridine; hydroxylamine-O-sulfonic acid / methanol / 20 °C

With pyridine; N,N-dimethyl-formamide; hydroxylamine-O-sulfonic acid; In methanol;

DOI:10.1021/jm060015t

upstream raw materials:

N'-(5-bromo-3-methyl-pyridin-2-yl)-N,N-dimethyl-formamidine

5-bromo-3-methyl-pyridin-2-ylamine

N,N-dimethyl-formamide dimethyl acetal