3',5'-bis-O-(tert-butyldimethylsilyl)-5-(3-phenyl-2-oxopropyl)-2'-deoxyuridine

Base Information

Chemical Name:3',5'-bis-O-(tert-butyldimethylsilyl)-5-(3-phenyl-2-oxopropyl)-2'-deoxyuridine
CAS No.:291525-19-4
Molecular Formula:C₃₀H₄₈N₂O₆Si₂
Molecular Weight:588.892
Hs Code.:

Synonyms:3',5'-bis-O-(tert-butyldimethylsilyl)-5-(3-phenyl-2-oxopropyl)-2'-deoxyuridine

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Chemical Property of 3',5'-bis-O-(tert-butyldimethylsilyl)-5-(3-phenyl-2-oxopropyl)-2'-deoxyuridine

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Technology Process of 3',5'-bis-O-(tert-butyldimethylsilyl)-5-(3-phenyl-2-oxopropyl)-2'-deoxyuridine

There total 5 articles about 3',5'-bis-O-(tert-butyldimethylsilyl)-5-(3-phenyl-2-oxopropyl)-2'-deoxyuridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 291525-18-3
3',5'-bis-O-(tert-butyldimethylsilyl)-5-(3-phenyl-2,2-(1,3-dithio))propyl-2'-deoxyuridine

: 291525-19-4
3',5'-bis-O-(tert-butyldimethylsilyl)-5-(3-phenyl-2-oxopropyl)-2'-deoxyuridine

Guidance literature:: With calcium carbonate; mercury dichloride; In water; acetonitrile; for 8h; Heating;
DOI:10.1021/jo000271s

Reference yield:

: 122-78-1
phenylacetaldehyde

: 291525-19-4
3',5'-bis-O-(tert-butyldimethylsilyl)-5-(3-phenyl-2-oxopropyl)-2'-deoxyuridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: 91 percent / BF₃*OEt₂ / 0.75 h / Heating

2.1: n-BuLi / tetrahydrofuran; cyclohexane / 12 h / -40 °C

2.2: 52.5 percent / tetrahydrofuran; cyclohexane / 12 h / -78 °C

3.1: 92 percent / HgCl₂; CaCO₃ / acetonitrile; H₂O / 8 h / Heating

With n-butyllithium; boron trifluoride diethyl etherate; calcium carbonate; mercury dichloride; In tetrahydrofuran; cyclohexane; water; acetonitrile; 1.1: Cyclization / 2.1: Metallation / 2.2: Substitution / 3.1: Ring cleavage;
DOI:10.1021/jo000271s

Reference yield:

: 31593-52-9
2-benzyl-1,3-dithiane

: 291525-19-4
3',5'-bis-O-(tert-butyldimethylsilyl)-5-(3-phenyl-2-oxopropyl)-2'-deoxyuridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-BuLi / tetrahydrofuran; cyclohexane / 12 h / -40 °C

1.2: 52.5 percent / tetrahydrofuran; cyclohexane / 12 h / -78 °C

2.1: 92 percent / HgCl₂; CaCO₃ / acetonitrile; H₂O / 8 h / Heating

With n-butyllithium; calcium carbonate; mercury dichloride; In tetrahydrofuran; cyclohexane; water; acetonitrile; 1.1: Metallation / 1.2: Substitution / 2.1: Ring cleavage;
DOI:10.1021/jo000271s