Cyclopropaneacetamide, 2-(hydroxymethyl)-N,N,3,3-tetramethyl-2-propyl-, (1R,2S)-rel- (9CI)

Base Information

Chemical Name:Cyclopropaneacetamide, 2-(hydroxymethyl)-N,N,3,3-tetramethyl-2-propyl-, (1R,2S)-rel- (9CI)
CAS No.:809237-24-9
Molecular Formula:C₁₃H₂₅NO₂
Molecular Weight:227.347
Hs Code.:
Mol file:809237-24-9.mol

Synonyms:Cyclopropaneacetamide, 2-(hydroxymethyl)-N,N,3,3-tetramethyl-2-propyl-, (1R,2S)-rel- (9CI)

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Cyclopropaneacetamide, 2-(hydroxymethyl)-N,N,3,3-tetramethyl-2-propyl-, (1R,2S)-rel- (9CI)

Chemical Property:

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Technology Process of Cyclopropaneacetamide, 2-(hydroxymethyl)-N,N,3,3-tetramethyl-2-propyl-, (1R,2S)-rel- (9CI)

There total 12 articles about Cyclopropaneacetamide, 2-(hydroxymethyl)-N,N,3,3-tetramethyl-2-propyl-, (1R,2S)-rel- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-methyl-4-(2-propyl-oxiranyl)-pent-2-enoic dimethylamide

: 809237-24-9
2-(2-hydroxymethyl-3,3-dimethyl-2-propyl-cyclopropyl)-N,N-dimethylacetamide

: 809237-24-9
2-(2-hydroxymethyl-3,3-dimethyl-2-propyl-cyclopropyl)-N,N-dimethylacetamide

Guidance literature:: With collidine hydrochloride; zinc; bis(cyclopentadienyl)titanium dichloride; In tetrahydrofuran; at 20 ℃; for 72h; Title compound not separated from byproducts;
DOI:10.1002/chem.200400685

Reference yield:

: 4-methyl-4-(2-propyl-oxiranyl)-pent-2-enoic dimethylamide

: 809237-24-9
2-(2-hydroxymethyl-3,3-dimethyl-2-propyl-cyclopropyl)-N,N-dimethylacetamide

: 809237-24-9
2-(2-hydroxymethyl-3,3-dimethyl-2-propyl-cyclopropyl)-N,N-dimethylacetamide

Guidance literature:: With collidine hydrochloride; zinc; bis(cyclopentadienyl)titanium dichloride; In tetrahydrofuran; at 20 ℃; for 72h; Title compound not separated from byproducts;
DOI:10.1002/chem.200400685

Reference yield:

: 809237-33-0
2,2-dimethyl-3-propyl-but-3-enal

: 809237-24-9
2-(2-hydroxymethyl-3,3-dimethyl-2-propyl-cyclopropyl)-N,N-dimethylacetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: NaH / diethyl ether / 0.08 h

1.2: 90 percent / diethyl ether / 16 h / 20 °C

2.1: 92 percent / mCPBA / CH₂Cl₂ / 16 h / 20 °C

3.1: collidine hydrochloride; Zn / [Cp₂TiCl₂] / tetrahydrofuran / 72 h / 20 °C

With collidine hydrochloride; sodium hydride; 3-chloro-benzenecarboperoxoic acid; zinc; bis(cyclopentadienyl)titanium dichloride; In tetrahydrofuran; diethyl ether; dichloromethane; 1.2: Horner-Wadsworth-Emmons olefination;
DOI:10.1002/chem.200400685