Technology Process of Boc-aminoPhe-OEt.CNCA
There total 4 articles about Boc-aminoPhe-OEt.CNCA which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
2-methoxy-ethanol; copper; potassium carbonate;
copper(I) oxide;
at 120 ℃;
for 1.5h;
Product distribution / selectivity;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: N-cyclohexyl-cyclohexanamine / ethyl acetate / 20 °C
2: hydrogen / palladium on carbon / N,N-dimethyl-formamide / 8 h
3: potassium carbonate; copper; 2-methoxy-ethanol / copper(I) oxide / 1.5 h / 120 °C / Inert atmosphere
With
2-methoxy-ethanol; hydrogen; copper; potassium carbonate; N-cyclohexyl-cyclohexanamine;
copper(I) oxide; palladium on carbon;
In
ethyl acetate; N,N-dimethyl-formamide;
3: Ullmann Coupling;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: hydrogen / palladium on carbon / N,N-dimethyl-formamide / 8 h
2: potassium carbonate; copper; 2-methoxy-ethanol / copper(I) oxide / 1.5 h / 120 °C / Inert atmosphere
With
2-methoxy-ethanol; hydrogen; copper; potassium carbonate;
copper(I) oxide; palladium on carbon;
In
N,N-dimethyl-formamide;
2: Ullmann Coupling;
