benzyl (6-chloro-5-nitro-2-(propylthio)pyrimidin-4-yl)((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)carbamate

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Chemical Name:benzyl (6-chloro-5-nitro-2-(propylthio)pyrimidin-4-yl)((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)carbamate
CAS No.:1427523-92-9
Molecular Formula:C₂₄H₂₁ClF₂N₄O₄S
Molecular Weight:534.971
Hs Code.:

Synonyms:benzyl (6-chloro-5-nitro-2-(propylthio)pyrimidin-4-yl)((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)carbamate

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Chemical Property of benzyl (6-chloro-5-nitro-2-(propylthio)pyrimidin-4-yl)((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)carbamate

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Technology Process of benzyl (6-chloro-5-nitro-2-(propylthio)pyrimidin-4-yl)((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)carbamate

There total 2 articles about benzyl (6-chloro-5-nitro-2-(propylthio)pyrimidin-4-yl)((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 145783-14-8
4,6-dichloro-5-nitro-2-(propylsulfanyl)pyrimidine

: 1427523-91-8
benzyl ((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)carbamate

: 1427523-92-9
benzyl (6-chloro-5-nitro-2-(propylthio)pyrimidin-4-yl)((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)carbamate

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 25 ℃; for 20h; Cooling with ice; Inert atmosphere;

Reference yield:

: 1006614-49-8,220352-38-5,1459719-81-3
(1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine

: 501-53-1,94274-21-2
benzyl chloroformate

: 1427523-92-9
benzyl (6-chloro-5-nitro-2-(propylthio)pyrimidin-4-yl)((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / ethyl acetate / 1 h / Cooling with ice

2: sodium hydride / N,N-dimethyl-formamide; mineral oil / 20 h / 25 °C / Cooling with ice; Inert atmosphere

With sodium hydride; triethylamine; In ethyl acetate; N,N-dimethyl-formamide; mineral oil;