2-[3-(9-Chloro-3-methyl-4-oxo-5H-isoxazolo[4,3-c]quinolin-5-yl)cyclohexyl]acetyl chloride

Base Information

Chemical Name:2-[3-(9-Chloro-3-methyl-4-oxo-5H-isoxazolo[4,3-c]quinolin-5-yl)cyclohexyl]acetyl chloride
CAS No.:347185-08-4
Molecular Formula:C₁₉H₁₈Cl₂N₂O₃
Molecular Weight:393.27
Hs Code.:

Synonyms:2-[3-(9-Chloro-3-methyl-4-oxo-5H-isoxazolo[4,3-c]quinolin-5-yl)cyclohexyl]acetyl chloride

Suppliers and Price of 2-[3-(9-Chloro-3-methyl-4-oxo-5H-isoxazolo[4,3-c]quinolin-5-yl)cyclohexyl]acetyl chloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-[3-(9-Chloro-3-methyl-4-oxo-5H-isoxazolo[4,3-c]quinolin-5-yl)cyclohexyl]acetyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-[3-(9-Chloro-3-methyl-4-oxo-5H-isoxazolo[4,3-c]quinolin-5-yl)cyclohexyl]acetyl chloride

There total 7 articles about 2-[3-(9-Chloro-3-methyl-4-oxo-5H-isoxazolo[4,3-c]quinolin-5-yl)cyclohexyl]acetyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 347184-60-5
2-[3-(9-chloro-3-methyl-4-oxo-5H-isoxazolo[4,3-c]quinolin-5-yl)cyclohexyl]acetic acid

: 347185-08-4
2-[3-(9-Chloro-3-methyl-4-oxo-5H-isoxazolo[4,3-c]quinolin-5-yl)cyclohexyl]acetyl chloride

Guidance literature:: With oxalyl dichloride; In dichloromethane; for 1h;
DOI:10.1016/j.bmcl.2005.08.075

Reference yield: 48.0%

: 347185-08-4
2-[3-(9-Chloro-3-methyl-4-oxo-5H-isoxazolo[4,3-c]quinolin-5-yl)cyclohexyl]acetyl chloride

: methyl 3-{[(t-butoxy)carbonylaminomethyl}benzoate

Guidance literature:

Reference yield:

: 14318-64-0
ethyl (3-nitrophenyI)acetate

: 347185-08-4
2-[3-(9-Chloro-3-methyl-4-oxo-5H-isoxazolo[4,3-c]quinolin-5-yl)cyclohexyl]acetyl chloride

Guidance literature:: Multi-step reaction with 5 steps

1: 72 percent / H₂ / Rh/C / ethanol / 18 h / 60 °C / 3102.89 Torr

2: 85 percent / Et₃N / CH₂Cl₂ / 1 h / 25 °C

3: 90 percent / t-BuOK / dimethylformamide / 18 h / 25 °C

4: 98 percent / NaOH / methanol

5: 100 percent / (COCl)2 / CH₂Cl₂ / 1 h

With sodium hydroxide; oxalyl dichloride; potassium tert-butylate; hydrogen; triethylamine; Rh on carbon; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2005.08.075