6-Benzothiazolol,2-bromo-(9CI)

Base Information

• Chemical Name: 6-Benzothiazolol,2-bromo-(9CI)
• CAS No.: 808755-67-1
• Molecular Formula: C7H4BrNOS
• Molecular Weight: 230.085
• Hs Code.: 2934200090
• Mol file: 808755-67-1.mol

Synonyms:2-Bromo-6-hydroxybenzothiazole;

Chemical Property of 6-Benzothiazolol,2-bromo-(9CI)

Chemical Property:

• Vapor Pressure: 4.06E-06mmHg at 25°C
• Refractive Index: 1.768
• Boiling Point: 373.8 °C at 760 mmHg
• PKA: 8.21±0.40(Predicted)
• Flash Point: 179.9 °C
• PSA: 61.36000
• Density: 1.903 g/cm³
• LogP: 2.76440
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2-Bromobenzo[d]thiazol-6-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-bromobenzo[d]thiazol-6-ol is a useful research chemical.

Technology Process of 6-Benzothiazolol,2-bromo-(9CI)

There total 3 articles about 6-Benzothiazolol,2-bromo-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-bromo-6-methoxy-1,3 benzothiazole (2941-58-4) → 6-hydroxy-2-bromo-benzothiazole (808755-67-1)

Guidance literature:

With boron tribromide; In dichloromethane; at 20 ℃; for 7h; Inert atmosphere;

Reference yield:

6-methoxybenzothiazol-2-ylamine (1747-60-0) → 6-hydroxy-2-bromo-benzothiazole (808755-67-1)

Guidance literature:

Multi-step reaction with 2 steps

1: copper(ll) bromide; isopentyl nitrite / acetonitrile / 65 °C

2: boron tribromide / dichloromethane / 2 h / 20 °C

With boron tribromide; copper(ll) bromide; isopentyl nitrite; In dichloromethane; acetonitrile;

DOI:10.1002/chem.201600278

Reference yield:

→ 6-hydroxy-2-bromo-benzothiazole (808755-67-1)

Guidance literature:

upstream raw materials:

2-bromo-6-methoxy-1,3 benzothiazole

6-methoxybenzothiazol-2-ylamine

Downstream raw materials:

2-amino-5-(ethoxymethoxy)benzenethiol

2-(4’-aminophenyl)-6-hydroxybenzothiazole

6-hydroxy-2-(4'-nitrophenyl)-1,3-benzothiazole

2-(4'-amino-3-nitrophenyl)-6-hydroxybenzothiazole