(R)-1-cyclohexyl-1,2,3,4-tetrahydroisoquinoline

Base Information

• Chemical Name: (R)-1-cyclohexyl-1,2,3,4-tetrahydroisoquinoline
• CAS No.: 1085538-45-9
• Molecular Formula: C₁₅H₂₁N
• Molecular Weight: 215.338
• Mol file: 1085538-45-9.mol

Synonyms:(R)-1-cyclohexyl-1,2,3,4-tetrahydroisoquinoline

Chemical Property of (R)-1-cyclohexyl-1,2,3,4-tetrahydroisoquinoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of (R)-1-cyclohexyl-1,2,3,4-tetrahydroisoquinoline

There total 6 articles about (R)-1-cyclohexyl-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

1-cyclohexyl-1,2,3,4-tetrahydroisoquinoline (87443-64-9) → (R)-1-cyclohexyl-1,2,3,4-tetrahydroisoquinoline (1085538-45-9)

Guidance literature:

1-cyclohexyl-1,2,3,4-tetrahydroisoquinoline; With N-Bromosuccinimide; bis(1,5-cyclooctadiene)diiridium(I) dichloride; sodium carbonate; (+)-(R)-[2,3,2',3'-tetrahydro-5,5'-bi(1,4-benzodioxin)-6,6'-diyl]bis(diphenylphosphane); In 1,2-dichloro-ethane; at 20 ℃; for 0.166667h;

With hydrogen; In 1,2-dichloro-ethane; at 30 ℃; for 24h; under 25858.1 Torr; enantioselective reaction;

DOI:10.1021/jacs.5b06659

Reference yield:

1-cyclohexyl-3,4-dihydroisoquinoline (65071-52-5) → (R)-1-cyclohexyl-1,2,3,4-tetrahydroisoquinoline (1085538-45-9) + (1S)-cyclohexyl-1,2,3,4-tetrahydroisoquinoline (1068158-37-1)

Guidance literature:

With silver hexafluoroantimonate; C₃₁H₃₆ClN₂O₂RhS; hydrogen; In dichloromethane; water; at 20 ℃; for 4h; under 15001.5 Torr; optical yield given as %ee; enantioselective reaction; Autoclave;

DOI:10.1021/ja8050958

Reference yield:

1-cyclohexyl-3,4-dihydroisoquinoline (65071-52-5) → (R)-1-cyclohexyl-1,2,3,4-tetrahydroisoquinoline (1085538-45-9)

Guidance literature:

With [N-[(1S,2S)-2-(amino-κN)-1,2-diphenylethyl]-4-methylbenzenesulfonamidato-κN][(1,2,3,4,5,6-η)-1,2,3,4,5,6-hexamethylbenzene](1,1,1-trifluoromethanesulfonato-κO)-ruthenium; hydrogen; at 25 ℃; under 38002.6 Torr; enantioselective reaction; Autoclave; Inert atmosphere; Ionic liquid;

DOI:10.1002/adsc.201300698

upstream raw materials:

1-cyclohexyl-3,4-dihydroisoquinoline

1-cyclohexyl-1,2,3,4-tetrahydroisoquinoline

phenethylamine

cyclohexanylcarbonyl chloride