o-tolyl-2-pyrazylmethanone

Base Information

• Chemical Name: o-tolyl-2-pyrazylmethanone
• CAS No.: 1184575-42-5
• Molecular Formula: C₁₂H₁₀N₂O
• Molecular Weight: 198.224
• Mol file: 1184575-42-5.mol

Synonyms:o-tolyl-2-pyrazylmethanone

Chemical Property of o-tolyl-2-pyrazylmethanone

Chemical Property:

Purity/Quality:

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Technology Process of o-tolyl-2-pyrazylmethanone

There total 1 articles about o-tolyl-2-pyrazylmethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-pyrazine carbonitrile (19847-12-2) + 2-methylphenyl bromide (95-46-5) → o-tolyl-2-pyrazylmethanone (1184575-42-5)

Guidance literature:

2-methylphenyl bromide; With magnesium; In tetrahydrofuran; Inert atmosphere;

2-pyrazine carbonitrile; In tetrahydrofuran; at 0 ℃; Inert atmosphere;

With hydrogenchloride; water; In diethyl ether; for 0.5h; Inert atmosphere;

DOI:10.1021/jo202204j

Reference yield:

o-tolyl-2-pyrazylmethanone (1184575-42-5) → (R)-(pyrazin-2-yl)(o-tolyl)methanol

Guidance literature:

With C₆₉H₇₈Cl₂N₂O₆P₂Ru; potassium tert-butylate; hydrogen; In isopropyl alcohol; at 25 ℃; for 16h; under 6080.41 Torr; optical yield given as %ee; enantioselective reaction; Autoclave; Inert atmosphere;

DOI:10.1021/jo202204j

upstream raw materials:

2-pyrazine carbonitrile

2-methylphenyl bromide