1-cyclopropyl-6-fluoro-7-{4-[2-(4-methoxy-benzyloxycarbonyl)-8-oxo-7-phenylacetylamino-5-thia-1-aza-bicyclo[4.3.0]oct-2-en-3-ylmethyl]-piperazin-1-yl}-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

Base Information

• Chemical Name: 1-cyclopropyl-6-fluoro-7-{4-[2-(4-methoxy-benzyloxycarbonyl)-8-oxo-7-phenylacetylamino-5-thia-1-aza-bicyclo[4.3.0]oct-2-en-3-ylmethyl]-piperazin-1-yl}-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid
• CAS No.: 143488-25-9
• Molecular Formula: C₄₁H₄₀FN₅O₈S
• Molecular Weight: 781.862
• Mol file: 143488-25-9.mol

Synonyms:1-cyclopropyl-6-fluoro-7-{4-[2-(4-methoxy-benzyloxycarbonyl)-8-oxo-7-phenylacetylamino-5-thia-1-aza-bicyclo[4.3.0]oct-2-en-3-ylmethyl]-piperazin-1-yl}-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

Chemical Property of 1-cyclopropyl-6-fluoro-7-{4-[2-(4-methoxy-benzyloxycarbonyl)-8-oxo-7-phenylacetylamino-5-thia-1-aza-bicyclo[4.3.0]oct-2-en-3-ylmethyl]-piperazin-1-yl}-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-cyclopropyl-6-fluoro-7-{4-[2-(4-methoxy-benzyloxycarbonyl)-8-oxo-7-phenylacetylamino-5-thia-1-aza-bicyclo[4.3.0]oct-2-en-3-ylmethyl]-piperazin-1-yl}-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

There total 2 articles about 1-cyclopropyl-6-fluoro-7-{4-[2-(4-methoxy-benzyloxycarbonyl)-8-oxo-7-phenylacetylamino-5-thia-1-aza-bicyclo[4.3.0]oct-2-en-3-ylmethyl]-piperazin-1-yl}-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.3%

ciprofloxacin (85721-33-1,178489-05-9,189257-90-7) + (6R,7R)-4-methoxybenzyl-3-(iodomethyl)-8-oxo-7-(2-phenylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate (101156-40-5) → 1-cyclopropyl-6-fluoro-7-{4-[2-(4-methoxy-benzyloxycarbonyl)-8-oxo-7-phenylacetylamino-5-thia-1-aza-bicyclo[4.3.0]oct-2-en-3-ylmethyl]-piperazin-1-yl}-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid (143488-25-9)

Guidance literature:

ciprofloxacin; With N-methyl-N-trimethylsilyl-2,2,2-trifluoroacetamide; In 1,4-dioxane; N,N-dimethyl-formamide; for 1h;

(6R,7R)-4-methoxybenzyl-3-(iodomethyl)-8-oxo-7-(2-phenylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate; In 1,4-dioxane; N,N-dimethyl-formamide; for 4h;

DOI:10.1016/j.bmcl.2006.08.045

Reference yield:

(6R,7R)-3-Chloromethyl-8-oxo-7-phenylacetylamino-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-methoxy-benzyl ester (104146-10-3) → 1-cyclopropyl-6-fluoro-7-{4-[2-(4-methoxy-benzyloxycarbonyl)-8-oxo-7-phenylacetylamino-5-thia-1-aza-bicyclo[4.3.0]oct-2-en-3-ylmethyl]-piperazin-1-yl}-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid (143488-25-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 94 percent / NaI / acetone / 1.5 h / 20 °C

2.1: N-methyl-N-(trimethylsilyl)trifluoroacetamide / dimethylformamide; dioxane / 1 h

2.2: 26.3 percent / dimethylformamide; dioxane / 4 h

With N-methyl-N-trimethylsilyl-2,2,2-trifluoroacetamide; sodium iodide; In 1,4-dioxane; N,N-dimethyl-formamide; acetone;

DOI:10.1016/j.bmcl.2006.08.045

Reference yield: 69.5%

1-cyclopropyl-6-fluoro-7-{4-[2-(4-methoxy-benzyloxycarbonyl)-8-oxo-7-phenylacetylamino-5-thia-1-aza-bicyclo[4.3.0]oct-2-en-3-ylmethyl]-piperazin-1-yl}-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid (143488-25-9) → 7-[4-(carboxy-8-oxo-7-phenylacetylamino-5-thia-1-aza-bicyclo[4.2.0]oct-2-en-3-ylmethyl)-piperazin-1-yl]-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

Guidance literature:

With methoxybenzene; trifluoroacetic acid; at 0 - 20 ℃; for 0.75h;

DOI:10.1016/j.bmcl.2006.08.045

upstream raw materials:

ciprofloxacin

(6R,7R)-4-methoxybenzyl-3-(iodomethyl)-8-oxo-7-(2-phenylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

(6R,7R)-3-Chloromethyl-8-oxo-7-phenylacetylamino-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-methoxy-benzyl ester