Technology Process of N-<4--N-prop-2-ynylamino>-2-fluorobenzoyl>-L-glutamic acid
There total 7 articles about N-<4--N-prop-2-ynylamino>-2-fluorobenzoyl>-L-glutamic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
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Multi-step reaction with 7 steps
1: 57 percent / Na2Cr2O7, cocnd. H2SO4 / acetic acid / 1 h / 90 °C
2: SOCl2 / toluene / 1.5 h / Heating
3: Et3N / CH2Cl2 / 2 h / 25 °C
4: 95 percent / iron powder, HOAc / 2 h / 50 °C
5: 60 percent / K2CO3 / toluene; dimethylformamide / 3 h / 110 - 120 °C
6: 90 percent / CaCO3 / N,N-dimethyl-acetamide / 18 h / 60 °C
7: 82 percent / aq. NaOH / ethanol / 24 h
With
sodium hydroxide; thionyl chloride; sodium dichromate; sulfuric acid; iron; potassium carbonate; acetic acid; triethylamine; calcium carbonate;
In
ethanol; dichloromethane; N,N-dimethyl acetamide; acetic acid; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00173a025
- Guidance literature:
-
Multi-step reaction with 6 steps
1: SOCl2 / toluene / 1.5 h / Heating
2: Et3N / CH2Cl2 / 2 h / 25 °C
3: 95 percent / iron powder, HOAc / 2 h / 50 °C
4: 60 percent / K2CO3 / toluene; dimethylformamide / 3 h / 110 - 120 °C
5: 90 percent / CaCO3 / N,N-dimethyl-acetamide / 18 h / 60 °C
6: 82 percent / aq. NaOH / ethanol / 24 h
With
sodium hydroxide; thionyl chloride; iron; potassium carbonate; acetic acid; triethylamine; calcium carbonate;
In
ethanol; dichloromethane; N,N-dimethyl acetamide; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00173a025
