benzyl [2-methyl-1-(2-methyl-4-{[(2S)-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl]methoxy}benzoyl)-1H-indol-3-yl]acetate

Base Information

Chemical Name:benzyl [2-methyl-1-(2-methyl-4-{[(2S)-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl]methoxy}benzoyl)-1H-indol-3-yl]acetate
CAS No.:502606-14-6
Molecular Formula:C₃₆H₃₄N₂O₅
Molecular Weight:574.676
Hs Code.:

Synonyms:benzyl [2-methyl-1-(2-methyl-4-{[(2S)-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl]methoxy}benzoyl)-1H-indol-3-yl]acetate

Suppliers and Price of benzyl [2-methyl-1-(2-methyl-4-{[(2S)-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl]methoxy}benzoyl)-1H-indol-3-yl]acetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of benzyl [2-methyl-1-(2-methyl-4-{[(2S)-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl]methoxy}benzoyl)-1H-indol-3-yl]acetate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of benzyl [2-methyl-1-(2-methyl-4-{[(2S)-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl]methoxy}benzoyl)-1H-indol-3-yl]acetate

There total 7 articles about benzyl [2-methyl-1-(2-methyl-4-{[(2S)-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl]methoxy}benzoyl)-1H-indol-3-yl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 502607-41-2
benzyl 2-(2-methyl-1H-indol-3-yl)acetate

: 603108-87-8
2-methyl-4-{[(2S)-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl]methoxy}benzoyl chloride

: 502606-14-6
benzyl [2-methyl-1-(2-methyl-4-{[(2S)-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl]methoxy}benzoyl)-1H-indol-3-yl]acetate

Guidance literature:: With tetrabutyl-ammonium chloride; sodium hydroxide; In dichloromethane; water; at 20 ℃; for 1h;
DOI:10.1016/j.bmc.2011.06.014

Reference yield:

: 1321937-95-4
2-methyl-4-{[(2S)-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl]methoxy}benzoic acid

: 502606-14-6
benzyl [2-methyl-1-(2-methyl-4-{[(2S)-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl]methoxy}benzoyl)-1H-indol-3-yl]acetate

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / 1,2-dimethoxyethane / 1 h / 40 °C

2: tetrabutyl-ammonium chloride; sodium hydroxide / dichloromethane; water / 1 h / 20 °C

With oxalyl dichloride; tetrabutyl-ammonium chloride; N,N-dimethyl-formamide; sodium hydroxide; In 1,2-dimethoxyethane; dichloromethane; water;
DOI:10.1016/j.bmc.2011.06.014

Reference yield:

: 1321937-71-6
methyl 2-methyl-4-{[(2S)-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl]methoxy}benzoate

: 502606-14-6
benzyl [2-methyl-1-(2-methyl-4-{[(2S)-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl]methoxy}benzoyl)-1H-indol-3-yl]acetate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / tetrahydrofuran; methanol; water / 3 h / 50 °C

2: oxalyl dichloride; N,N-dimethyl-formamide / 1,2-dimethoxyethane / 1 h / 40 °C

3: tetrabutyl-ammonium chloride; sodium hydroxide / dichloromethane; water / 1 h / 20 °C

With oxalyl dichloride; tetrabutyl-ammonium chloride; N,N-dimethyl-formamide; sodium hydroxide; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; water;
DOI:10.1016/j.bmc.2011.06.014