(Z)-4-(4-tert-Butoxycarbonylamino-phenyl)-3-methyl-4-oxo-but-2-enoic acid ethyl ester

Base Information

Chemical Name:(Z)-4-(4-tert-Butoxycarbonylamino-phenyl)-3-methyl-4-oxo-but-2-enoic acid ethyl ester
CAS No.:203259-36-3
Molecular Formula:C₁₈H₂₃NO₅
Molecular Weight:333.384
Hs Code.:

Synonyms:(Z)-4-(4-tert-Butoxycarbonylamino-phenyl)-3-methyl-4-oxo-but-2-enoic acid ethyl ester

Suppliers and Price of (Z)-4-(4-tert-Butoxycarbonylamino-phenyl)-3-methyl-4-oxo-but-2-enoic acid ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of (Z)-4-(4-tert-Butoxycarbonylamino-phenyl)-3-methyl-4-oxo-but-2-enoic acid ethyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

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Hazard Codes:

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Technology Process of (Z)-4-(4-tert-Butoxycarbonylamino-phenyl)-3-methyl-4-oxo-but-2-enoic acid ethyl ester

There total 4 articles about (Z)-4-(4-tert-Butoxycarbonylamino-phenyl)-3-methyl-4-oxo-but-2-enoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 203259-33-0
(Z)-4-(4-Amino-phenyl)-3-methyl-4-oxo-but-2-enoic acid ethyl ester

: 203259-36-3
(Z)-4-(4-tert-Butoxycarbonylamino-phenyl)-3-methyl-4-oxo-but-2-enoic acid ethyl ester

Guidance literature:: In chloroform; for 192h; Ambient temperature;
DOI:10.1248/cpb.46.84

Reference yield:

: 616-02-4
citraconic acid anhydride

: 203259-36-3
(Z)-4-(4-tert-Butoxycarbonylamino-phenyl)-3-methyl-4-oxo-but-2-enoic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 34 percent / AlCl₃, DMF / 3 h / 70 °C

2: 95 percent / HCl / 24 h / Ambient temperature

3: 68 percent / CHCl₃ / 192 h / Ambient temperature

With hydrogenchloride; aluminium trichloride; N,N-dimethyl-formamide; In chloroform;
DOI:10.1248/cpb.46.84

Reference yield:

: 139052-03-2
3-(p-Acetamidobenzoyl)-crotonsaeure

: 203259-36-3
(Z)-4-(4-tert-Butoxycarbonylamino-phenyl)-3-methyl-4-oxo-but-2-enoic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / HCl / 24 h / Ambient temperature

2: 68 percent / CHCl₃ / 192 h / Ambient temperature

With hydrogenchloride; In chloroform;
DOI:10.1248/cpb.46.84