2-((2-((4-carbamimidoylphenoxy)methyl)-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-6-yl)(3-fluorobenzyl)amino)acetic acid

Base Information

Chemical Name:2-((2-((4-carbamimidoylphenoxy)methyl)-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-6-yl)(3-fluorobenzyl)amino)acetic acid
CAS No.:1370705-83-1
Molecular Formula:C₂₇H₂₉FN₄O₄
Molecular Weight:492.55
Hs Code.:

Synonyms:2-((2-((4-carbamimidoylphenoxy)methyl)-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-6-yl)(3-fluorobenzyl)amino)acetic acid

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Chemical Property of 2-((2-((4-carbamimidoylphenoxy)methyl)-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-6-yl)(3-fluorobenzyl)amino)acetic acid

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Technology Process of 2-((2-((4-carbamimidoylphenoxy)methyl)-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-6-yl)(3-fluorobenzyl)amino)acetic acid

There total 9 articles about 2-((2-((4-carbamimidoylphenoxy)methyl)-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-6-yl)(3-fluorobenzyl)amino)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: C₂HF₃O₂*3C₂₉H₃₃FN₄O₄

: 1370705-83-1
2-((2-((4-carbamimidoylphenoxy)methyl)-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-6-yl)(3-fluorobenzyl)amino)acetic acid

Guidance literature:: C₂HF₃O₂*3C₂₉H₃₃FN₄O₄; With lithium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 2h;

With trifluoroacetic acid; In water; pH=2;
DOI:10.1016/j.ejmech.2012.01.059

Reference yield:

: 1056737-08-6
(2,4-dimethyl-6-nitro-3,4-dihydro-2H-1,4-benzoxazin-2-yl)methanol

: 1370705-83-1
2-((2-((4-carbamimidoylphenoxy)methyl)-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-6-yl)(3-fluorobenzyl)amino)acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 48 h / Reflux

2.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 2 h / 20 °C

3.1: methanol / 5 h / 20 °C / Inert atmosphere; Molecular sieve

4.1: sodium tetrahydroborate / methanol / 2 h / 20 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 24 h / 100 °C

6.1: hydrogenchloride / ethanol / 24.5 h / 20 °C

6.2: 24 h / 20 °C

7.1: lithium hydroxide / tetrahydrofuran; methanol / 2 h / 20 °C

7.2: pH 2

With hydrogenchloride; sodium tetrahydroborate; di-isopropyl azodicarboxylate; palladium 10% on activated carbon; hydrogen; potassium carbonate; triphenylphosphine; lithium hydroxide; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide; 1.1: Mitsunobu reaction / 6.1: Pinner amidine synthesis / 6.2: Pinner amidine synthesis;
DOI:10.1016/j.ejmech.2012.01.059

Reference yield:

: 1056737-23-5
4-[(6-amino-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl)methoxy]benzonitrile

: 1370705-83-1
2-((2-((4-carbamimidoylphenoxy)methyl)-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-6-yl)(3-fluorobenzyl)amino)acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: methanol / 5 h / 20 °C / Inert atmosphere; Molecular sieve

2.1: sodium tetrahydroborate / methanol / 2 h / 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 24 h / 100 °C

4.1: hydrogenchloride / ethanol / 24.5 h / 20 °C

4.2: 24 h / 20 °C

5.1: lithium hydroxide / tetrahydrofuran; methanol / 2 h / 20 °C

5.2: pH 2

With hydrogenchloride; sodium tetrahydroborate; potassium carbonate; lithium hydroxide; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide; 4.1: Pinner amidine synthesis / 4.2: Pinner amidine synthesis;
DOI:10.1016/j.ejmech.2012.01.059