methyl 1-(5-(4-(methylthio)phenyl)pent-4-yn-1-yl)-1H-indole-3-carboxylate

Base Information

Chemical Name:methyl 1-(5-(4-(methylthio)phenyl)pent-4-yn-1-yl)-1H-indole-3-carboxylate
CAS No.:1360871-53-9
Molecular Formula:C₂₂H₂₁NO₂S
Molecular Weight:363.48
Hs Code.:

Synonyms:methyl 1-(5-(4-(methylthio)phenyl)pent-4-yn-1-yl)-1H-indole-3-carboxylate

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Chemical Property of methyl 1-(5-(4-(methylthio)phenyl)pent-4-yn-1-yl)-1H-indole-3-carboxylate

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Technology Process of methyl 1-(5-(4-(methylthio)phenyl)pent-4-yn-1-yl)-1H-indole-3-carboxylate

There total 3 articles about methyl 1-(5-(4-(methylthio)phenyl)pent-4-yn-1-yl)-1H-indole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 56041-85-1
4-ethynylthioanisole

: methyl 1-(3-iodopropyl)-1H-indole-3-carboxylate methyl 1-(3-iodopropyl)-1H-indole-3-carboxylate

: 1360871-53-9
methyl 1-(5-(4-(methylthio)phenyl)pent-4-yn-1-yl)-1H-indole-3-carboxylate

Guidance literature:: 4-ethynylthioanisole; With Bis<2-(N,N-dimethylamino)aethyl>aether; ethylmagnesium bromide; In tetrahydrofuran; at 20 ℃; for 2.25h;

methyl 1-(3-iodopropyl)-1H-indole-3-carboxylate methyl 1-(3-iodopropyl)-1H-indole-3-carboxylate; With [((Me)NN₂)NiCl]; In tetrahydrofuran; at 20 ℃; for 6h;
DOI:10.1002/anie.201105964

Reference yield:

: 3446-89-7
4-(Methylthio)benzaldehyde

: 1360871-53-9
methyl 1-(5-(4-(methylthio)phenyl)pent-4-yn-1-yl)-1H-indole-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triphenylphosphine / dichloromethane / 0.25 h / 0 °C

1.2: 0.55 h / 0 °C

2.1: n-butyllithium / tetrahydrofuran / 0.67 h / -78 °C / Inert atmosphere

3.1: Bis<2-(N,N-dimethylamino)aethyl>aether; ethylmagnesium bromide / tetrahydrofuran / 2.25 h / 20 °C

3.2: 6 h / 20 °C

With n-butyllithium; Bis<2-(N,N-dimethylamino)aethyl>aether; ethylmagnesium bromide; triphenylphosphine; In tetrahydrofuran; dichloromethane; 3.2: Kumada coupling reaction;
DOI:10.1002/anie.201105964

Reference yield:

: 1-(2,2-Dibromo-vinyl)-4-methylsulfanyl-benzene

: 1360871-53-9
methyl 1-(5-(4-(methylthio)phenyl)pent-4-yn-1-yl)-1H-indole-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran / 0.67 h / -78 °C / Inert atmosphere

2.1: Bis<2-(N,N-dimethylamino)aethyl>aether; ethylmagnesium bromide / tetrahydrofuran / 2.25 h / 20 °C

2.2: 6 h / 20 °C

With n-butyllithium; Bis<2-(N,N-dimethylamino)aethyl>aether; ethylmagnesium bromide; In tetrahydrofuran; 2.2: Kumada coupling reaction;
DOI:10.1002/anie.201105964