N-benzyl-5-methyl-1-phenylhex-1-yn-3-amine

Base Information

• Chemical Name: N-benzyl-5-methyl-1-phenylhex-1-yn-3-amine
• CAS No.: 1083003-99-9
• Molecular Formula: C₂₀H₂₃N
• Molecular Weight: 277.409
• Mol file: 1083003-99-9.mol

Synonyms:N-benzyl-5-methyl-1-phenylhex-1-yn-3-amine

Chemical Property of N-benzyl-5-methyl-1-phenylhex-1-yn-3-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-benzyl-5-methyl-1-phenylhex-1-yn-3-amine

There total 2 articles about N-benzyl-5-methyl-1-phenylhex-1-yn-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

phenylacetylene (536-74-3) + benzylamine (100-46-9) + isovaleraldehyde (590-86-3) → N-benzyl-5-methyl-1-phenylhex-1-yn-3-amine (1083003-99-9)

Guidance literature:

With copper(l) chloride; copper dichloride; In water; at 110 ℃; for 0.416667h; Reagent/catalyst; Temperature; Time; Microwave irradiation; Green chemistry;

DOI:10.1039/c4ra16005c

Reference yield:

N-benzyl-3-methylbutan-1-imine (63502-00-1) + phenylacetylene (536-74-3) → N-benzyl-5-methyl-1-phenylhex-1-yn-3-amine (1083003-99-9)

Guidance literature:

phenylacetylene; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 0.5h;

With boron trifluoride-tetrahydrofuran complex; In tetrahydrofuran; for 0.25h;

N-benzyl-3-methylbutan-1-imine; In tetrahydrofuran; at -78 ℃; for 3h;

DOI:10.1055/s-2008-1078029

Reference yield: 97.0%

N-benzyl-5-methyl-1-phenylhex-1-yn-3-amine (1083003-99-9) + phenyl isothiocyanate (103-72-0) → 1,4-dibenzyl-5-isobutyl-3-phenyl-1H-imidazole-2(3H)-thione

Guidance literature:

With sodium hydroxide; In N,N-dimethyl-formamide; at 25 ℃; for 2h; Reagent/catalyst; Solvent; regioselective reaction; Inert atmosphere;

DOI:10.1021/ol502871r

upstream raw materials:

N-benzyl-3-methylbutan-1-imine

phenylacetylene

benzylamine

isovaleraldehyde

Downstream raw materials:

C₂₀H₂₂N₂O

Refernces

• 1、 Ranjan, Alok,Deore, Abhijit S.,Yerande, Swapnil G.,Dethe, Dattatraya H.. "Thiol–Yne Coupling of Propargylamine under Solvent-Free Conditions by Bond Anion Relay Chemistry: An Efficient Synthesis of Thiazolidin-2-ylideneamine". . p. 4130 - 4139. Retrieved 2017.
• 2、 Bariwal, Jitender B.,Ermolat'Ev, Denis S.,Van Der Eycken, Erik V.. "Efficient microwave-assisted synthesis of secondary alkylproparglamines by using A3-coupling with primary aliphatic amines". supporting information; experimental part. p. 3281 - 3284. Retrieved 2010/06/19.