3-{4-[2-(5-methyl-2-phenyloxazol-4-yl)ethoxy]phenyl}-2-phenoxypropionic acid ethyl ester

Base Information

Chemical Name:3-{4-[2-(5-methyl-2-phenyloxazol-4-yl)ethoxy]phenyl}-2-phenoxypropionic acid ethyl ester
CAS No.:698347-47-6
Molecular Formula:C₂₉H₂₉NO₅
Molecular Weight:471.553
Hs Code.:

Synonyms:3-{4-[2-(5-methyl-2-phenyloxazol-4-yl)ethoxy]phenyl}-2-phenoxypropionic acid ethyl ester

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Chemical Property of 3-{4-[2-(5-methyl-2-phenyloxazol-4-yl)ethoxy]phenyl}-2-phenoxypropionic acid ethyl ester

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Technology Process of 3-{4-[2-(5-methyl-2-phenyloxazol-4-yl)ethoxy]phenyl}-2-phenoxypropionic acid ethyl ester

There total 5 articles about 3-{4-[2-(5-methyl-2-phenyloxazol-4-yl)ethoxy]phenyl}-2-phenoxypropionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 170861-68-4
toluene-4-sulfonic acid 2-(5-methyl-2-phenyl-oxazol-4-yl)-ethyl ester

: 197299-09-5
3-(4-hydroxyphenyl)-2-phenylpropionic acid ethyl ester

: 698347-47-6
3-{4-[2-(5-methyl-2-phenyloxazol-4-yl)ethoxy]phenyl}-2-phenoxypropionic acid ethyl ester

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 55 ℃; for 16h;
DOI:10.1021/jm0342616

Reference yield:

: 4397-53-9
p-benzyloxybenzaldehyde

: 698347-47-6
3-{4-[2-(5-methyl-2-phenyloxazol-4-yl)ethoxy]phenyl}-2-phenoxypropionic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: LDA / tetrahydrofuran; toluene; heptane / 1 h / -78 °C

2: 30 percent / BF₃*Et₂O; triethylsilane / CH₂Cl₂ / 0 - 20 °C

3: 91 percent / H₂ / Pd/C / ethanol / 20 h

4: 63 percent / Cs₂CO₃ / dimethylformamide / 16 h / 55 °C

With triethylsilane; boron trifluoride diethyl etherate; hydrogen; caesium carbonate; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; ethanol; n-heptane; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm0342616

Reference yield:

: 2555-49-9
phenoxyacetic acid ethyl ester

: 698347-47-6
3-{4-[2-(5-methyl-2-phenyloxazol-4-yl)ethoxy]phenyl}-2-phenoxypropionic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: LDA / tetrahydrofuran; toluene; heptane / 1 h / -78 °C

2: 30 percent / BF₃*Et₂O; triethylsilane / CH₂Cl₂ / 0 - 20 °C

3: 91 percent / H₂ / Pd/C / ethanol / 20 h

4: 63 percent / Cs₂CO₃ / dimethylformamide / 16 h / 55 °C

With triethylsilane; boron trifluoride diethyl etherate; hydrogen; caesium carbonate; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; ethanol; n-heptane; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm0342616