(R)-N-(1-phenyl-2-(3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)propan-2-yl)acetamide

Base Information

Chemical Name:(R)-N-(1-phenyl-2-(3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)propan-2-yl)acetamide
CAS No.:1263941-29-2
Molecular Formula:C₂₄H₂₁F₃N₄O
Molecular Weight:438.452
Hs Code.:

Synonyms:(R)-N-(1-phenyl-2-(3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)propan-2-yl)acetamide

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Chemical Property of (R)-N-(1-phenyl-2-(3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)propan-2-yl)acetamide

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Technology Process of (R)-N-(1-phenyl-2-(3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)propan-2-yl)acetamide

There total 7 articles about (R)-N-(1-phenyl-2-(3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)propan-2-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1263941-25-8
N-(1-phenyl-2-(3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)propan-2-yl)acetamide

: 1263941-29-2
(R)-N-(1-phenyl-2-(3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)propan-2-yl)acetamide

: (S)-N-(1-phenyl-2-(3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)propan-2-yl)acetamide

Guidance literature:: ChiralPak IA column; In tetrahydrofuran; methanol; carbon dioxide; at 30 ℃; Resolution of racemate;

Reference yield:

: 1264296-51-6
1-phenyl-2-(3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)propan-2-amine

: 1263941-29-2
(R)-N-(1-phenyl-2-(3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)propan-2-yl)acetamide

: (S)-N-(1-phenyl-2-(3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)propan-2-yl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

2: ChiralPak IA column / carbon dioxide; tetrahydrofuran; methanol / 30 °C / Resolution of racemate

With N-ethyl-N,N-diisopropylamine; ChiralPak IA column; In tetrahydrofuran; methanol; dichloromethane; carbon dioxide;

Reference yield:

: 1264296-47-0
tert-butyl 3-hydroxy-2-methyl-1-phenylpent-4-yn-2-ylcarbamate

: 1263941-29-2
(R)-N-(1-phenyl-2-(3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)propan-2-yl)acetamide

: (S)-N-(1-phenyl-2-(3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)propan-2-yl)acetamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: Dess-Martin periodane / dichloromethane / 20 °C

1.2: 0.33 h

2.1: dichloromethane / 0 - 20 °C

3.1: hydrogenchloride / ethanol; water / 70 °C

4.1: trifluoroacetic acid / dichloromethane / 20 °C

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

6.1: ChiralPak IA column / carbon dioxide; tetrahydrofuran; methanol / 30 °C / Resolution of racemate

With hydrogenchloride; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; ChiralPak IA column; In tetrahydrofuran; methanol; ethanol; dichloromethane; carbon dioxide; water;