2-[(3R,4S)-3-amino-4-(2,4,5-trifluorophenyl)pyrrolidin-1-yl]-pyrimidine-5-carboxylic acid cyclopropyl-[1-(3-isopropyl[1,2,4]oxadiazol-5-yl)piperidin-4-yl]amide hydrochloride

Base Information

Chemical Name:2-[(3R,4S)-3-amino-4-(2,4,5-trifluorophenyl)pyrrolidin-1-yl]-pyrimidine-5-carboxylic acid cyclopropyl-[1-(3-isopropyl[1,2,4]oxadiazol-5-yl)piperidin-4-yl]amide hydrochloride
CAS No.:1376608-12-6
Molecular Formula:C₂₈H₃₃F₃N₈O₂*ClH
Molecular Weight:607.079
Hs Code.:

2-[(3R,4S)-3-amino-4-(2,4,5-trifluorophenyl)pyrrolidin-1-yl]-pyrimidine-5-carboxylic acid cyclopropyl-[1-(3-isopropyl[1,2,4]oxadiazol-5-yl)piperidin-4-yl]amide hydrochloride

Synonyms:2-[(3R,4S)-3-amino-4-(2,4,5-trifluorophenyl)pyrrolidin-1-yl]-pyrimidine-5-carboxylic acid cyclopropyl-[1-(3-isopropyl[1,2,4]oxadiazol-5-yl)piperidin-4-yl]amide hydrochloride

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Chemical Property of 2-[(3R,4S)-3-amino-4-(2,4,5-trifluorophenyl)pyrrolidin-1-yl]-pyrimidine-5-carboxylic acid cyclopropyl-[1-(3-isopropyl[1,2,4]oxadiazol-5-yl)piperidin-4-yl]amide hydrochloride

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Technology Process of 2-[(3R,4S)-3-amino-4-(2,4,5-trifluorophenyl)pyrrolidin-1-yl]-pyrimidine-5-carboxylic acid cyclopropyl-[1-(3-isopropyl[1,2,4]oxadiazol-5-yl)piperidin-4-yl]amide hydrochloride

There total 5 articles about 2-[(3R,4S)-3-amino-4-(2,4,5-trifluorophenyl)pyrrolidin-1-yl]-pyrimidine-5-carboxylic acid cyclopropyl-[1-(3-isopropyl[1,2,4]oxadiazol-5-yl)piperidin-4-yl]amide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 35613-84-4
isobutyramide oxime

: 1376609-95-8
[(3R,4S)-1-{5-[(1-cyanopiperidin-4-yl)cyclopropylcarbamoyl]pyrimidin-2-yl}-4-(2,4,5-trifluorophenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester

: 1376608-12-6
2-[(3R,4S)-3-amino-4-(2,4,5-trifluorophenyl)pyrrolidin-1-yl]-pyrimidine-5-carboxylic acid cyclopropyl-[1-(3-isopropyl[1,2,4]oxadiazol-5-yl)piperidin-4-yl]amide hydrochloride

Guidance literature:: isobutyramide oxime; [(3R,4S)-1-{5-[(1-cyanopiperidin-4-yl)cyclopropylcarbamoyl]pyrimidin-2-yl}-4-(2,4,5-trifluorophenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester; With zinc(II) chloride; In diethyl ether; ethanol; at 20 ℃;

With hydrogenchloride; In 1,4-dioxane; diethyl ether; ethanol; at 60 ℃; for 16h;

Reference yield:

: 1376609-84-5
2-[(3R,4S)-3-tert-butoxycarbonylamino-4-(2,4,5-trifluorophenyl)pyrrolidin-1-yl]pyrimidine-5-carboxylic acid methyl ester

: 1376608-12-6
2-[(3R,4S)-3-amino-4-(2,4,5-trifluorophenyl)pyrrolidin-1-yl]-pyrimidine-5-carboxylic acid cyclopropyl-[1-(3-isopropyl[1,2,4]oxadiazol-5-yl)piperidin-4-yl]amide hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.33 h / 20 °C

1.2: 16 h / 20 °C

2.1: palladium 10% on activated carbon; hydrogen / ethanol / 75 - 80 °C / 37503.8 - 75007.5 Torr

3.1: sodium hydrogencarbonate / dichloromethane; water / 1.25 h / 20 °C

4.1: zinc(II) chloride / diethyl ether; ethanol / 20 °C

4.2: 16 h / 60 °C

With palladium 10% on activated carbon; hydrogen; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; zinc(II) chloride; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; water;

Reference yield:

: 387358-47-6
(1-benzylpiperidin-4-yl)cyclopropylamine

: 1376608-12-6
2-[(3R,4S)-3-amino-4-(2,4,5-trifluorophenyl)pyrrolidin-1-yl]-pyrimidine-5-carboxylic acid cyclopropyl-[1-(3-isopropyl[1,2,4]oxadiazol-5-yl)piperidin-4-yl]amide hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.33 h / 20 °C

1.2: 16 h / 20 °C

2.1: palladium 10% on activated carbon; hydrogen / ethanol / 75 - 80 °C / 37503.8 - 75007.5 Torr

3.1: sodium hydrogencarbonate / dichloromethane; water / 1.25 h / 20 °C

4.1: zinc(II) chloride / diethyl ether; ethanol / 20 °C

4.2: 16 h / 60 °C

With palladium 10% on activated carbon; hydrogen; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; zinc(II) chloride; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; water;