2-Diazo-malonic acid (Z)-(S)-1-benzyl-4-phenylsulfanyl-but-2-enyl ester ethyl ester

Base Information

Chemical Name:2-Diazo-malonic acid (Z)-(S)-1-benzyl-4-phenylsulfanyl-but-2-enyl ester ethyl ester
CAS No.:122663-88-1
Molecular Formula:C₂₂H₂₂N₂O₄S
Molecular Weight:410.494
Hs Code.:

Synonyms:2-Diazo-malonic acid (Z)-(S)-1-benzyl-4-phenylsulfanyl-but-2-enyl ester ethyl ester

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Chemical Property of 2-Diazo-malonic acid (Z)-(S)-1-benzyl-4-phenylsulfanyl-but-2-enyl ester ethyl ester

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Technology Process of 2-Diazo-malonic acid (Z)-(S)-1-benzyl-4-phenylsulfanyl-but-2-enyl ester ethyl ester

There total 6 articles about 2-Diazo-malonic acid (Z)-(S)-1-benzyl-4-phenylsulfanyl-but-2-enyl ester ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 122663-99-4
Malonic acid (Z)-1-benzyl-4-phenylsulfanyl-but-2-enyl ester ethyl ester

: 122663-88-1
2-Diazo-malonic acid (Z)-(S)-1-benzyl-4-phenylsulfanyl-but-2-enyl ester ethyl ester

Guidance literature:: With toluenesulfonyl azide; triethylamine; In acetonitrile; at 45 ℃; for 48h;
DOI:10.1016/S0040-4020(01)85601-5

Reference yield:

: 5651-88-7
phenyl propargyl sulfide

: 122663-88-1
2-Diazo-malonic acid (Z)-(S)-1-benzyl-4-phenylsulfanyl-but-2-enyl ester ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) ethylmagnesium bromide / 2.) THF, 0 deg C

2: 82 percent / pyridine / tetrahydrofuran / 3 h / 0 °C

3: 78 percent / H₂ / 5percent Pd-BaSO₄ / methanol

4: 97 percent / p-toluenesulfonyl azide, triethylamine / acetonitrile / 40 h / 45 °C

With pyridine; 4-toluenesulfonyl azide; ethylmagnesium bromide; hydrogen; triethylamine; palladium on barium sulfate; In tetrahydrofuran; methanol; acetonitrile;
DOI:10.1016/S0040-4039(00)99523-6

Reference yield:

: 122663-96-1
Malonic acid 1-benzyl-4-phenylsulfanyl-but-2-ynyl ester ethyl ester

: 122663-88-1
2-Diazo-malonic acid (Z)-(S)-1-benzyl-4-phenylsulfanyl-but-2-enyl ester ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 78 percent / H₂ / 5percent Pd-BaSO₄ / methanol

2: 97 percent / p-toluenesulfonyl azide, triethylamine / acetonitrile / 40 h / 45 °C

With 4-toluenesulfonyl azide; hydrogen; triethylamine; palladium on barium sulfate; In methanol; acetonitrile;
DOI:10.1016/S0040-4039(00)99523-6