2'-O-(tert-butyldimethylsilyl)-5'-O-(p,p'-dimethoxytrityl)uridine 3'-O-(allyl N,N-disopropylphosphoramidite)

Base Information

Chemical Name:2'-O-(tert-butyldimethylsilyl)-5'-O-(p,p'-dimethoxytrityl)uridine 3'-O-(allyl N,N-disopropylphosphoramidite)
CAS No.:185628-22-2
Molecular Formula:C₄₅H₆₂N₃O₉PSi
Molecular Weight:848.061
Hs Code.:

Synonyms:2'-O-(tert-butyldimethylsilyl)-5'-O-(p,p'-dimethoxytrityl)uridine 3'-O-(allyl N,N-disopropylphosphoramidite)

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Chemical Property of 2'-O-(tert-butyldimethylsilyl)-5'-O-(p,p'-dimethoxytrityl)uridine 3'-O-(allyl N,N-disopropylphosphoramidite)

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Technology Process of 2'-O-(tert-butyldimethylsilyl)-5'-O-(p,p'-dimethoxytrityl)uridine 3'-O-(allyl N,N-disopropylphosphoramidite)

There total 1 articles about 2'-O-(tert-butyldimethylsilyl)-5'-O-(p,p'-dimethoxytrityl)uridine 3'-O-(allyl N,N-disopropylphosphoramidite) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 108554-72-9
(allyloxy)bis(diisopropylamino)phosphine

: 81246-80-2
5'-O-dimethoxytrityl-2'-O-tert-butyldimethylsilyl uridine

: 185628-22-2
2'-O-(tert-butyldimethylsilyl)-5'-O-(p,p'-dimethoxytrityl)uridine 3'-O-(allyl N,N-disopropylphosphoramidite)

Guidance literature:: With N-phenylimidazolium trifluoromethanesulfonatesalt; In dichloromethane; at 25 ℃; for 1.5h;
DOI:10.1021/ja010078v

Reference yield:

: 171612-65-0
2',3'-O-di<(allyloxy)carbonyl>uridine

: 185628-22-2
2'-O-(tert-butyldimethylsilyl)-5'-O-(p,p'-dimethoxytrityl)uridine 3'-O-(allyl N,N-disopropylphosphoramidite)

: C₅₆H₆₇N₄O₁₉PSi

Guidance literature:: With N-phenylimidazolium trifluoromethanesulfonatesalt; In acetonitrile; at 25 ℃; for 0.25h;
DOI:10.1021/ja010078v

Reference yield:

: 185628-22-2
2'-O-(tert-butyldimethylsilyl)-5'-O-(p,p'-dimethoxytrityl)uridine 3'-O-(allyl N,N-disopropylphosphoramidite)

: C₅₆H₆₇N₄O₂₀PSi

Guidance literature:: Multi-step reaction with 2 steps

1: N-(phenyl)imidazolium triflate; MS 3A / acetonitrile / 0.25 h / 25 °C

2: TBHP / acetonitrile; toluene / 0.08 h / 25 °C

With tert.-butylhydroperoxide; N-phenylimidazolium trifluoromethanesulfonatesalt; In toluene; acetonitrile;
DOI:10.1021/ja010078v