2-(2-hydroxyethyl)-1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinolin-6-yl 2,4-dinitrobenzenesulfonate

Base Information

Chemical Name:2-(2-hydroxyethyl)-1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinolin-6-yl 2,4-dinitrobenzenesulfonate
CAS No.:1384524-86-0
Molecular Formula:C₂₀H₁₃N₃O₁₀S
Molecular Weight:487.403
Hs Code.:

Synonyms:2-(2-hydroxyethyl)-1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinolin-6-yl 2,4-dinitrobenzenesulfonate

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Chemical Property of 2-(2-hydroxyethyl)-1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinolin-6-yl 2,4-dinitrobenzenesulfonate

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Technology Process of 2-(2-hydroxyethyl)-1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinolin-6-yl 2,4-dinitrobenzenesulfonate

There total 3 articles about 2-(2-hydroxyethyl)-1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinolin-6-yl 2,4-dinitrobenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.9%

: 892-16-0
6-hydroxy-2-(2-hydroxyethyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione

: 1656-44-6
2,4-dinitrobenzenesulfonyl chloride

: 1384524-86-0
2-(2-hydroxyethyl)-1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinolin-6-yl 2,4-dinitrobenzenesulfonate

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 4h;
DOI:10.1016/j.tet.2012.04.110

Reference yield:

: 52559-37-2
N-hydroxyethyl-4-bromine-1,8-naphthalimide

: 1384524-86-0
2-(2-hydroxyethyl)-1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinolin-6-yl 2,4-dinitrobenzenesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / 90 °C / Inert atmosphere

2: dihydrogen peroxide / N,N-dimethyl-formamide / 2 h / 20 °C

3: triethylamine / dichloromethane / 4 h / 0 - 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; dihydrogen peroxide; potassium acetate; triethylamine; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2012.04.110

Reference yield:

: 1401064-97-8
N-(2-hydroxyethyl)-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1,8-naphthalimide

: 1384524-86-0
2-(2-hydroxyethyl)-1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinolin-6-yl 2,4-dinitrobenzenesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1: dihydrogen peroxide / N,N-dimethyl-formamide / 2 h / 20 °C

2: triethylamine / dichloromethane / 4 h / 0 - 20 °C

With dihydrogen peroxide; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2012.04.110