8-aminooctanoic acid 2-{4-[2,4-dioxo-thiazolidin-(5Z)-ylidenemethyl]-phenoxymethyl}-2,5,7,8-tetramethyl-chroman-6-yl ester trifluoroacetate

Base Information

Chemical Name:8-aminooctanoic acid 2-{4-[2,4-dioxo-thiazolidin-(5Z)-ylidenemethyl]-phenoxymethyl}-2,5,7,8-tetramethyl-chroman-6-yl ester trifluoroacetate
CAS No.:1375483-21-8
Molecular Formula:C₂HF₃O₂*C₃₂H₄₀N₂O₆S
Molecular Weight:694.769
Hs Code.:

Synonyms:8-aminooctanoic acid 2-{4-[2,4-dioxo-thiazolidin-(5Z)-ylidenemethyl]-phenoxymethyl}-2,5,7,8-tetramethyl-chroman-6-yl ester trifluoroacetate

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Chemical Property of 8-aminooctanoic acid 2-{4-[2,4-dioxo-thiazolidin-(5Z)-ylidenemethyl]-phenoxymethyl}-2,5,7,8-tetramethyl-chroman-6-yl ester trifluoroacetate

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Technology Process of 8-aminooctanoic acid 2-{4-[2,4-dioxo-thiazolidin-(5Z)-ylidenemethyl]-phenoxymethyl}-2,5,7,8-tetramethyl-chroman-6-yl ester trifluoroacetate

There total 8 articles about 8-aminooctanoic acid 2-{4-[2,4-dioxo-thiazolidin-(5Z)-ylidenemethyl]-phenoxymethyl}-2,5,7,8-tetramethyl-chroman-6-yl ester trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1375483-19-4
8-tert-butoxycarbonylamino-octanoic acid 2-{4-[2,4-dioxo-thiazolidin-(5Z)-ylidenemethyl]-phenoxymethyl}-2,5,7,8-tetramethyl-chroman-6-yl ester

: 76-05-1
trifluoroacetic acid

: 1375483-21-8
8-aminooctanoic acid 2-{4-[2,4-dioxo-thiazolidin-(5Z)-ylidenemethyl]-phenoxymethyl}-2,5,7,8-tetramethyl-chroman-6-yl ester trifluoroacetate

Guidance literature:: In dichloromethane; at 20 ℃; for 0.75h;
DOI:10.1016/j.ejmech.2012.02.044

Reference yield:

: 1375483-11-6
carbonic acid tert-butyl ester 2-hydroxymethyl-2,5,7,8-tetramethyl-chroman-6-yl ester

: 1375483-21-8
8-aminooctanoic acid 2-{4-[2,4-dioxo-thiazolidin-(5Z)-ylidenemethyl]-phenoxymethyl}-2,5,7,8-tetramethyl-chroman-6-yl ester trifluoroacetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyridine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

2.1: potassium carbonate / N,N-dimethyl-formamide / 48 h / 2 °C / Inert atmosphere

3.1: piperidine / ethanol / 12 h / Inert atmosphere; Reflux

4.1: trifluoroacetic acid / dichloromethane / 1 h

5.1: triethylamine; isobutyl chloroformate / dichloromethane / 1 h / Cooling with ice

5.2: 12 h / 20 °C

6.1: dichloromethane / 0.75 h / 20 °C

With piperidine; pyridine; potassium carbonate; triethylamine; trifluoroacetic acid; isobutyl chloroformate; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2012.02.044

Reference yield:

: 56305-04-5,53188-07-1
trolox

: 1375483-21-8
8-aminooctanoic acid 2-{4-[2,4-dioxo-thiazolidin-(5Z)-ylidenemethyl]-phenoxymethyl}-2,5,7,8-tetramethyl-chroman-6-yl ester trifluoroacetate

Guidance literature:: Multi-step reaction with 9 steps

1.1: toluene-4-sulfonic acid / 12 h / Reflux

2.1: dmap / dichloromethane / 2 h / 20 °C / Inert atmosphere

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

4.1: pyridine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

5.1: potassium carbonate / N,N-dimethyl-formamide / 48 h / 2 °C / Inert atmosphere

6.1: piperidine / ethanol / 12 h / Inert atmosphere; Reflux

7.1: trifluoroacetic acid / dichloromethane / 1 h

8.1: triethylamine; isobutyl chloroformate / dichloromethane / 1 h / Cooling with ice

8.2: 12 h / 20 °C

9.1: dichloromethane / 0.75 h / 20 °C

With piperidine; pyridine; dmap; lithium aluminium tetrahydride; potassium carbonate; toluene-4-sulfonic acid; triethylamine; trifluoroacetic acid; isobutyl chloroformate; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2012.02.044