(2'R,4'S,6'S)-1,4'-dimethyl-6'-(phenoxymethyl)-3',4',5',6'-tetrahydrospiro[indoline-3,2'-pyran]-2-one

Base Information

Chemical Name:(2'R,4'S,6'S)-1,4'-dimethyl-6'-(phenoxymethyl)-3',4',5',6'-tetrahydrospiro[indoline-3,2'-pyran]-2-one
CAS No.:1177441-29-0
Molecular Formula:C₂₁H₂₃NO₃
Molecular Weight:337.419
Hs Code.:

Synonyms:(2'R,4'S,6'S)-1,4'-dimethyl-6'-(phenoxymethyl)-3',4',5',6'-tetrahydrospiro[indoline-3,2'-pyran]-2-one

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Chemical Property of (2'R,4'S,6'S)-1,4'-dimethyl-6'-(phenoxymethyl)-3',4',5',6'-tetrahydrospiro[indoline-3,2'-pyran]-2-one

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Technology Process of (2'R,4'S,6'S)-1,4'-dimethyl-6'-(phenoxymethyl)-3',4',5',6'-tetrahydrospiro[indoline-3,2'-pyran]-2-one

There total 3 articles about (2'R,4'S,6'S)-1,4'-dimethyl-6'-(phenoxymethyl)-3',4',5',6'-tetrahydrospiro[indoline-3,2'-pyran]-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 14271-46-6
(3,3-dimethoxy-N-methyl)indoline-2-one

: 1177441-16-5
(S)-trimethyl(4-methyl-1-phenoxypent-4-en-2-yloxy)silane

: 1177441-29-0
(2'R,4'S,6'S)-1,4'-dimethyl-6'-(phenoxymethyl)-3',4',5',6'-tetrahydrospiro[indoline-3,2'-pyran]-2-one

Guidance literature:: (3,3-dimethoxy-N-methyl)indoline-2-one; (S)-trimethyl(4-methyl-1-phenoxypent-4-en-2-yloxy)silane; With trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at -40 - 20 ℃; for 14h; Molecular sieve;

With Crabtree's catalyst; hydrogen; In dichloromethane; at 20 ℃; for 6h; under 760.051 Torr; optical yield given as %de;
DOI:10.1021/ol901201k

Reference yield: 62.0%

: 1177441-19-8
(2'R,6'S)-1,4'-dimethyl-6'-(phenoxymethyl)-3',6'-dihydrospiro[indoline-3,2'-pyran]-2-one

: 1177441-27-8
(2'R,4'R,6'S)-1,4'-dimethyl-6'-(phenoxymethyl)-3',4',5',6'-tetrahydrospiro[indoline-3,2'-pyran]-2-one

: 1177441-29-0
(2'R,4'S,6'S)-1,4'-dimethyl-6'-(phenoxymethyl)-3',4',5',6'-tetrahydrospiro[indoline-3,2'-pyran]-2-one

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; under 2585.81 Torr; optical yield given as %de;
DOI:10.1021/ol901201k

Reference yield:

: 1177441-21-2
(2'R,6'S)-1,4'-dimethyl-6'-(phenoxymethyl)-5',6'-dihydrospiro[indoline-3,2'-pyran]-2-one

: 1177441-27-8
(2'R,4'R,6'S)-1,4'-dimethyl-6'-(phenoxymethyl)-3',4',5',6'-tetrahydrospiro[indoline-3,2'-pyran]-2-one

: 1177441-29-0
(2'R,4'S,6'S)-1,4'-dimethyl-6'-(phenoxymethyl)-3',4',5',6'-tetrahydrospiro[indoline-3,2'-pyran]-2-one

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; under 2585.81 Torr; optical yield given as %de;
DOI:10.1021/ol901201k