Technology Process of (2S)-1-(4-methylphenylsulfonyl)-2-vinylpyrrolidin-4-one
There total 9 articles about (2S)-1-(4-methylphenylsulfonyl)-2-vinylpyrrolidin-4-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 98 percent / triethylamine / CH2Cl2 / 10 h / cooling
2.1: 97 percent / imidazole / dimethylformamide / 2 h / 20 °C
3.1: 95 percent / NaBH4; LiCl / methanol / 12 h / 20 °C
4.1: oxalyl chloride; dimethyl sulfoxide / CH2Cl2 / 1.5 h
5.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C
5.2: 871 mg / tetrahydrofuran / 8 h / -78 °C
6.1: tetra-n-butylammonium fluoride / tetrahydrofuran / 1 h / 20 °C
7.1: 225 mg / pyridinium chlorochromate; Celite / CH2Cl2 / 10 h / 20 °C
With
1H-imidazole; sodium tetrahydroborate; n-butyllithium; oxalyl dichloride; Celite; tetrabutyl ammonium fluoride; dimethyl sulfoxide; triethylamine; pyridinium chlorochromate; lithium chloride;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
4.1: Swern oxidation / 5.2: Wittig olefination;
DOI:10.3987/COM-05-10407
- Guidance literature:
-
With
Celite; pyridinium chlorochromate;
In
dichloromethane;
at 20 ℃;
for 10h;
DOI:10.3987/COM-05-10407
- Guidance literature:
-
Multi-step reaction with 2 steps
1: tetra-n-butylammonium fluoride / tetrahydrofuran / 1 h / 20 °C
2: 225 mg / pyridinium chlorochromate; Celite / CH2Cl2 / 10 h / 20 °C
With
Celite; tetrabutyl ammonium fluoride; pyridinium chlorochromate;
In
tetrahydrofuran; dichloromethane;
DOI:10.3987/COM-05-10407
