N-(4-methyl-3-(5-methyl-4-(m-tolylamino)pyrimidin-2-ylamino)phenyl)acrylamide

Base Information

Chemical Name:N-(4-methyl-3-(5-methyl-4-(m-tolylamino)pyrimidin-2-ylamino)phenyl)acrylamide
CAS No.:1202755-93-8
Molecular Formula:C₂₂H₂₃N₅O
Molecular Weight:373.458
Hs Code.:

Synonyms:N-(4-methyl-3-(5-methyl-4-(m-tolylamino)pyrimidin-2-ylamino)phenyl)acrylamide

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Chemical Property of N-(4-methyl-3-(5-methyl-4-(m-tolylamino)pyrimidin-2-ylamino)phenyl)acrylamide

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Technology Process of N-(4-methyl-3-(5-methyl-4-(m-tolylamino)pyrimidin-2-ylamino)phenyl)acrylamide

There total 6 articles about N-(4-methyl-3-(5-methyl-4-(m-tolylamino)pyrimidin-2-ylamino)phenyl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 4.0%

: 1202759-65-6
C₁₉H₂₁N₅

: 814-68-6,25189-84-8
acryloyl chloride

: 1202755-93-8
N-(4-methyl-3-(5-methyl-4-(m-tolylamino)pyrimidin-2-ylamino)phenyl)acrylamide

Guidance literature:: In 1-methyl-pyrrolidin-2-one; at 0 - 20 ℃; for 1h;

Reference yield:

: 660838-05-1
t-butyl 3-amino-4-methylphenylcarbamate

: 1202755-93-8
N-(4-methyl-3-(5-methyl-4-(m-tolylamino)pyrimidin-2-ylamino)phenyl)acrylamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / palladium diacetate / toluene / 12 h / Reflux; Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 0 - 20 °C

2.2: Cooling with ice

3.1: 1-methyl-pyrrolidin-2-one / 1 h / 0 - 20 °C

With caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; trifluoroacetic acid; palladium diacetate; In 1-methyl-pyrrolidin-2-one; dichloromethane; toluene;

Reference yield:

: 1780-31-0
2,6-dichloro-5-methylpyrimidine

: 1202755-93-8
N-(4-methyl-3-(5-methyl-4-(m-tolylamino)pyrimidin-2-ylamino)phenyl)acrylamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine / butan-1-ol / 0.5 h / 120 °C / Microwave irradiation

2.1: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / palladium diacetate / toluene / 12 h / Reflux; Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 0 - 20 °C

3.2: Cooling with ice

4.1: 1-methyl-pyrrolidin-2-one / 1 h / 0 - 20 °C

With caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium diacetate; In 1-methyl-pyrrolidin-2-one; dichloromethane; toluene; butan-1-ol;