ethyl trans-4-{[5-(5-chloro-1H-benzimidazol-2-yl)-2,3'-bipyridin-6'-yl]oxy}cyclohexanecarboxylate

Base Information

Chemical Name:ethyl trans-4-{[5-(5-chloro-1H-benzimidazol-2-yl)-2,3'-bipyridin-6'-yl]oxy}cyclohexanecarboxylate
CAS No.:1438250-63-5
Molecular Formula:C₂₆H₂₅ClN₄O₃
Molecular Weight:476.962
Hs Code.:

Synonyms:ethyl trans-4-{[5-(5-chloro-1H-benzimidazol-2-yl)-2,3'-bipyridin-6'-yl]oxy}cyclohexanecarboxylate

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Chemical Property of ethyl trans-4-{[5-(5-chloro-1H-benzimidazol-2-yl)-2,3'-bipyridin-6'-yl]oxy}cyclohexanecarboxylate

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Technology Process of ethyl trans-4-{[5-(5-chloro-1H-benzimidazol-2-yl)-2,3'-bipyridin-6'-yl]oxy}cyclohexanecarboxylate

There total 6 articles about ethyl trans-4-{[5-(5-chloro-1H-benzimidazol-2-yl)-2,3'-bipyridin-6'-yl]oxy}cyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1442646-25-4
ethyl trans-4-[(5-formyl-2,3'-bipyridin-6'-yl)oxy]cyclohexanecarboxylate

: 95-83-0
4-Chloro-1,2-phenylenediamine

: 1438250-63-5
ethyl trans-4-{[5-(5-chloro-1H-benzimidazol-2-yl)-2,3'-bipyridin-6'-yl]oxy}cyclohexanecarboxylate

Guidance literature:: With potassium peroxymonosulfate; In water; N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/ml400168h

Reference yield:

: 13466-38-1
5-bromopyridin-2-ol

: 1438250-63-5
ethyl trans-4-{[5-(5-chloro-1H-benzimidazol-2-yl)-2,3'-bipyridin-6'-yl]oxy}cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 40 h / 20 - 55 °C / Inert atmosphere

2: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 80 °C / Inert atmosphere

3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / N,N-dimethyl-formamide; water / 80 °C / Inert atmosphere

4: potassium peroxymonosulfate / N,N-dimethyl-formamide; water / 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; di-isopropyl azodicarboxylate; potassium peroxymonosulfate; potassium acetate; sodium carbonate; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; 1: |Mitsunobu Displacement / 3: |Suzuki Coupling;
DOI:10.1021/ml400168h

Reference yield:

: 149806-06-4
6-bromonicotinaldehyde

: 1438250-63-5
ethyl trans-4-{[5-(5-chloro-1H-benzimidazol-2-yl)-2,3'-bipyridin-6'-yl]oxy}cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / N,N-dimethyl-formamide; water / 80 °C / Inert atmosphere

2: potassium peroxymonosulfate / N,N-dimethyl-formamide; water / 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium peroxymonosulfate; sodium carbonate; In water; N,N-dimethyl-formamide; 1: |Suzuki Coupling;
DOI:10.1021/ml400168h