4'-[3-[(tert-butoxycarbonyl)[(2R)-2-hydroxy-2-phenylethyl)amino]propyl]-3-(cyclohexyloxy)-4-biphenylcarboxylic acid

Base Information

Chemical Name:4'-[3-[(tert-butoxycarbonyl)[(2R)-2-hydroxy-2-phenylethyl)amino]propyl]-3-(cyclohexyloxy)-4-biphenylcarboxylic acid
CAS No.:855479-53-7
Molecular Formula:C₃₅H₄₃NO₆
Molecular Weight:573.73
Hs Code.:

Synonyms:4'-[3-[(tert-butoxycarbonyl)[(2R)-2-hydroxy-2-phenylethyl)amino]propyl]-3-(cyclohexyloxy)-4-biphenylcarboxylic acid

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Chemical Property of 4'-[3-[(tert-butoxycarbonyl)[(2R)-2-hydroxy-2-phenylethyl)amino]propyl]-3-(cyclohexyloxy)-4-biphenylcarboxylic acid

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Technology Process of 4'-[3-[(tert-butoxycarbonyl)[(2R)-2-hydroxy-2-phenylethyl)amino]propyl]-3-(cyclohexyloxy)-4-biphenylcarboxylic acid

There total 1 articles about 4'-[3-[(tert-butoxycarbonyl)[(2R)-2-hydroxy-2-phenylethyl)amino]propyl]-3-(cyclohexyloxy)-4-biphenylcarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 855480-84-1
methyl 4'-[3-[(tert-butoxycarbonyl)-[(2R)-2-hydroxy-2-phenylethyl]amino]propyl]-3-(cyclohexyloxy)-4-biphenylcarboxylate

: 855479-53-7
4'-[3-[(tert-butoxycarbonyl)[(2R)-2-hydroxy-2-phenylethyl)amino]propyl]-3-(cyclohexyloxy)-4-biphenylcarboxylic acid

Guidance literature:: methyl 4'-[3-[(tert-butoxycarbonyl)-[(2R)-2-hydroxy-2-phenylethyl]amino]propyl]-3-(cyclohexyloxy)-4-biphenylcarboxylate; With sodium hydroxide; water; In methanol; at 20 - 50 ℃; for 21h;

With hydrogenchloride; In methanol; water; at 20 ℃;

Reference yield:

: 855479-53-7
4'-[3-[(tert-butoxycarbonyl)[(2R)-2-hydroxy-2-phenylethyl)amino]propyl]-3-(cyclohexyloxy)-4-biphenylcarboxylic acid

: 24243-71-8
propane-1-sulfonamide

: 855479-54-8
tert-butyl [3-[3'-(cyclohexyloxy)-4'-[[(propylsulfonyl)amino]carbonyl]-4-biphenylyl]propyl][(2R)-2-hydroxy-2-phenylethyl]carbamate

Guidance literature:: 4'-[3-[(tert-butoxycarbonyl)[(2R)-2-hydroxy-2-phenylethyl)amino]propyl]-3-(cyclohexyloxy)-4-biphenylcarboxylic acid; With 1,1'-carbonyldiimidazole; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 5h;

propane-1-sulfonamide; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In DMF (N,N-dimethyl-formamide); at 50 ℃; for 14h;