2-<5-(2-chloroethoxy)-2-nitrophenyl>-1,4-diphenyl-1,2,4,5-tetrahydroimidazole

Base Information

• Chemical Name: 2-<5-(2-chloroethoxy)-2-nitrophenyl>-1,4-diphenyl-1,2,4,5-tetrahydroimidazole
• CAS No.: 116005-60-8
• Molecular Formula: C₂₃H₂₂ClN₃O₃
• Molecular Weight: 423.899
• Mol file: 116005-60-8.mol

Synonyms:2-<5-(2-chloroethoxy)-2-nitrophenyl>-1,4-diphenyl-1,2,4,5-tetrahydroimidazole

Chemical Property of 2-<5-(2-chloroethoxy)-2-nitrophenyl>-1,4-diphenyl-1,2,4,5-tetrahydroimidazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-<5-(2-chloroethoxy)-2-nitrophenyl>-1,4-diphenyl-1,2,4,5-tetrahydroimidazole

There total 1 articles about 2-<5-(2-chloroethoxy)-2-nitrophenyl>-1,4-diphenyl-1,2,4,5-tetrahydroimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

5-(2-chloroethoxy)-2-nitrobenzaldehyde (116005-59-5) + N,N'-diphenylethylenediamine (150-61-8) → 2-<5-(2-chloroethoxy)-2-nitrophenyl>-1,4-diphenyl-1,2,4,5-tetrahydroimidazole (116005-60-8)

Guidance literature:

With acetic acid; In methanol; Ambient temperature;

DOI:10.1021/jm00119a015

Reference yield: 62.0%

N-cyclohexyl-N-methylmalonamide monoethyl ester (86647-91-8) + 2-<5-(2-chloroethoxy)-2-nitrophenyl>-1,4-diphenyl-1,2,4,5-tetrahydroimidazole (116005-60-8) → N-cyclohexyl-N-methyl-2-(ethoxycarbonyl)-4-(3-formyl-4-nitrophenoxy)butyramide (116005-61-9)

Guidance literature:

With tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran; 1.) room temperature, 1 h, 2.) reflux, 5 days;

DOI:10.1021/jm00119a015

Reference yield:

2-<5-(2-chloroethoxy)-2-nitrophenyl>-1,4-diphenyl-1,2,4,5-tetrahydroimidazole (116005-60-8) → N-cyclohexyl-N-methyl-2-carboxy-4<(1,2,3,5-tetrahydro-2-oxoimidazo<2,1-b>quinazolin-7-yl)oxy>butyramide (116005-63-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 62 percent / 1.) NaH, 2.) tetra-n-butylammonium iodide / tetrahydrofuran / 1.) room temperature, 1 h, 2.) reflux, 5 days

3: 86 percent / aq. KOH / ethanol / 1 h / Ambient temperature

With potassium hydroxide; tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran; ethanol;

DOI:10.1021/jm00119a015

upstream raw materials:

5-(2-chloroethoxy)-2-nitrobenzaldehyde

N,N'-diphenylethylenediamine

Downstream raw materials:

N-cyclohexyl-N-methyl-2-(ethoxycarbonyl)-4-(3-formyl-4-nitrophenoxy)butyramide

N-cyclohexyl-N-methyl-2-carboxy-4<(1,2,3,5-tetrahydro-2-oxoimidazo<2,1-b>quinazolin-7-yl)oxy>butyramide

N-cyclohexyl-N-methyl-2-(ethoxycarbonyl)-4<(1,2,3,5-tetrahydro-2-oxoimidazo<2,1-b>quinazolin-7-yl)oxy>butyramide

Refernces