5-methyl-1-((1R,2R,3R)-tetrahydro-2-hydroxy-3-(1,1-dimethylethyldiphenyl)-silyloxymethyl-1-furanyl)-2,4(1H,3H)-pyrimidinedione

Base Information

Chemical Name:5-methyl-1-((1R,2R,3R)-tetrahydro-2-hydroxy-3-(1,1-dimethylethyldiphenyl)-silyloxymethyl-1-furanyl)-2,4(1H,3H)-pyrimidinedione
CAS No.:287933-75-9
Molecular Formula:C₂₆H₃₂N₂O₅Si
Molecular Weight:480.636
Hs Code.:

Synonyms:5-methyl-1-((1R,2R,3R)-tetrahydro-2-hydroxy-3-(1,1-dimethylethyldiphenyl)-silyloxymethyl-1-furanyl)-2,4(1H,3H)-pyrimidinedione

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Chemical Property of 5-methyl-1-((1R,2R,3R)-tetrahydro-2-hydroxy-3-(1,1-dimethylethyldiphenyl)-silyloxymethyl-1-furanyl)-2,4(1H,3H)-pyrimidinedione

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Technology Process of 5-methyl-1-((1R,2R,3R)-tetrahydro-2-hydroxy-3-(1,1-dimethylethyldiphenyl)-silyloxymethyl-1-furanyl)-2,4(1H,3H)-pyrimidinedione

There total 9 articles about 5-methyl-1-((1R,2R,3R)-tetrahydro-2-hydroxy-3-(1,1-dimethylethyldiphenyl)-silyloxymethyl-1-furanyl)-2,4(1H,3H)-pyrimidinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 448896-37-5
1-[4-(tert-butyl-diphenyl-silanyloxymethyl)-3-trimethylsilanyloxy-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

: 287933-75-9
5-methyl-1-((1R,2R,3R)-tetrahydro-2-hydroxy-3-(1,1-dimethylethyldiphenyl)-silyloxymethyl-1-furanyl)-2,4(1H,3H)-pyrimidinedione

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; methanol; at 0 - 20 ℃; for 0.5h;
DOI:10.1007/s007060200024

Reference yield: 78.0%

: 287933-73-7
tert-Butyl-[(1R,4R,5R)-1-(2,6-dioxa-bicyclo[3.1.0]hex-4-yl)methoxy]-diphenyl-silane

: 7288-28-0
2,4-bis(trimethylsiloxy)-5-methylpyrimidine

: 287933-75-9
5-methyl-1-((1R,2R,3R)-tetrahydro-2-hydroxy-3-(1,1-dimethylethyldiphenyl)-silyloxymethyl-1-furanyl)-2,4(1H,3H)-pyrimidinedione

Guidance literature:: With hydrogenchloride; In chloroform-d1; water;
DOI:10.1016/S0040-4039(00)00467-6

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 287933-75-9
5-methyl-1-((1R,2R,3R)-tetrahydro-2-hydroxy-3-(1,1-dimethylethyldiphenyl)-silyloxymethyl-1-furanyl)-2,4(1H,3H)-pyrimidinedione

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / Et₃N; DMAP

2: 100 percent / 5 percent Na/Hg; NaH₂PO₄ / methanol; tetrahydrofuran

3: dimethyl dioxirane / CH₂Cl₂

4: 78 percent / HCl / CDCl₃; H₂O

With hydrogenchloride; dmap; sodium dihydrogenphosphate; sodium amalgam; 3,3-dimethyldioxirane; triethylamine; In tetrahydrofuran; methanol; chloroform-d1; dichloromethane; water; 1: Silylation / 2: Reduction / 3: Epoxidation / 4: Alkylation;
DOI:10.1016/S0040-4039(00)00467-6