(E)-ethyl 2-cyano-2-(2-nitrophenylsulfonyloxyimino)acetate

Base Information

• Chemical Name: (E)-ethyl 2-cyano-2-(2-nitrophenylsulfonyloxyimino)acetate
• CAS No.: 1441409-96-6
• Molecular Formula: C₁₁H₉N₃O₇S
• Molecular Weight: 327.274
• Mol file: 1441409-96-6.mol

Synonyms:(E)-ethyl 2-cyano-2-(2-nitrophenylsulfonyloxyimino)acetate

Chemical Property of (E)-ethyl 2-cyano-2-(2-nitrophenylsulfonyloxyimino)acetate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of (E)-ethyl 2-cyano-2-(2-nitrophenylsulfonyloxyimino)acetate

There total 2 articles about (E)-ethyl 2-cyano-2-(2-nitrophenylsulfonyloxyimino)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

ethyl (2E)-cyano(hydroxyimino)ethanoate (56503-39-0) + 2-Nitrobenzenesulfonyl chloride (1694-92-4) → (E)-ethyl 2-cyano-2-(2-nitrophenylsulfonyloxyimino)acetate (1441409-96-6)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 25 ℃; for 2h; Inert atmosphere;

DOI:10.1021/jo500292m

Reference yield: 75.0%

2-Nitrobenzenesulfonyl chloride (1694-92-4) + ethyl cyanoglyoxylate-2-oxime (3849-21-6) → (E)-ethyl 2-cyano-2-(2-nitrophenylsulfonyloxyimino)acetate (1441409-96-6)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 2h; Inert atmosphere;

DOI:10.1002/ejoc.201201571

Reference yield: 84.0%

(E)-ethyl 2-cyano-2-(2-nitrophenylsulfonyloxyimino)acetate (1441409-96-6) + methoxycarbonylmethylamine (616-34-2) → N-2-nitrobenzenesulfonamideglycine methyl ester (215056-52-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; Green chemistry;

DOI:10.1002/ejoc.201201571

upstream raw materials:

2-Nitrobenzenesulfonyl chloride

ethyl cyanoglyoxylate-2-oxime

ethyl (2E)-cyano(hydroxyimino)ethanoate

Downstream raw materials:

N-2-nitrobenzenesulfonamideglycine methyl ester

p-chlorobenzaldehyde O-[(4-methylphenyl)sulphonyl]oxime

(E)-4-chlorobenzaldehyde-O-ethoxycarbonyloxime

(E)-acetophenone-O-ethoxycarbonyloxime