2-fluoro-4-iodo-6-chloroaniline

Base Information

• Chemical Name: 2-fluoro-4-iodo-6-chloroaniline
• CAS No.: 702640-40-2
• Molecular Formula: C₆H₄ClFIN
• Molecular Weight: 271.46

Synonyms:2-fluoro-4-iodo-6-chloroaniline

Chemical Property of 2-fluoro-4-iodo-6-chloroaniline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-fluoro-4-iodo-6-chloroaniline

There total 1 articles about 2-fluoro-4-iodo-6-chloroaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloro-6-fluoroaniline (363-51-9) → 2-fluoro-4-iodo-6-chloroaniline (702640-40-2)

Guidance literature:

With iodine; sodium hydrogencarbonate; In water; at 60 ℃; for 72h;

Reference yield: 78.0%

2-fluoro-4-iodo-6-chloroaniline (702640-40-2) + acrylonitrile (107-13-1,25014-41-9) → (E)-3-(4-amino-3-chloro-5-fluorophenyl)acrylonitrile

Guidance literature:

With palladium 10% on activated carbon; tetrabutylammomium bromide; sodium acetate; tris-(o-tolyl)phosphine; In N,N-dimethyl acetamide; at 140 ℃; for 12h; Inert atmosphere;

DOI:10.1021/acsinfecdis.9b00229

Reference yield:

2-fluoro-4-iodo-6-chloroaniline (702640-40-2) → trans-4-((4-((2-chloro-4-(2-cyanovinyl)-6-fluorophenyl)amino)quinazolin-2-yl)amino)benzonitrile

Guidance literature:

Multi-step reaction with 3 steps

1: palladium 10% on activated carbon; tris-(o-tolyl)phosphine; tetrabutylammomium bromide; sodium acetate / N,N-dimethyl acetamide / 12 h / 140 °C / Inert atmosphere

2: palladium diacetate; DavePhos; potassium phosphate / N,N-dimethyl acetamide / 12 h / 140 °C / Inert atmosphere

3: butan-1-ol / Reflux

With potassium phosphate; palladium 10% on activated carbon; tetrabutylammomium bromide; sodium acetate; palladium diacetate; tris-(o-tolyl)phosphine; DavePhos; In N,N-dimethyl acetamide; butan-1-ol;

DOI:10.1021/acsinfecdis.9b00229

upstream raw materials:

2-chloro-6-fluoroaniline

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 702640-40-2 2-fluoro-4-iodo-6-chloroaniline

Send

Send

Metric Ton KG G Pound L ML

Send

Send