4-Chloro-2-fluoro-3-Methoxybenzaldehyde, 97%

Base Information

• Chemical Name: 4-Chloro-2-fluoro-3-Methoxybenzaldehyde, 97%
• CAS No.: 1002344-97-9
• Molecular Formula: C₈H₆ClFO₂
• Molecular Weight: 188.586
• Hs Code.: 2913000090
• Mol file: 1002344-97-9.mol

Synonyms:4-chloro-2-fluoro-3-methoxybenzaldehyde

Chemical Property of 4-Chloro-2-fluoro-3-Methoxybenzaldehyde, 97%

Chemical Property:

• Sensitive.: Air Sensitive

Purity/Quality:

99% ^*data from raw suppliers

4-Chloro-2-fluoro-3-methoxybenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 4-Chloro-2-fluoro-3-methoxybenzaldehyde is widely utilized as an intermediate in organic synthesis.

Technology Process of 4-Chloro-2-fluoro-3-Methoxybenzaldehyde, 97%

There total 3 articles about 4-Chloro-2-fluoro-3-Methoxybenzaldehyde, 97% which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

N,N-dimethyl-formamide (68-12-2,33513-42-7) + 1-chloro-3-fluoro-2-methoxybenzene (53145-38-3) → 4-chloro-2-fluoro-3-methoxybenzaldehyde (1002344-97-9)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; hexane; cyclohexane; at -50 ℃; Flow reactor;

DOI:10.1021/op500213j

Reference yield: 61.0%

1-bromo-4-chloro-2-fluoro-3-methoxybenzene (943832-96-0) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 4-chloro-2-fluoro-3-methoxybenzaldehyde (1002344-97-9)

Guidance literature:

1-bromo-4-chloro-2-fluoro-3-methoxybenzene; With n-butyllithium; In diethyl ether; hexane; at -78 - -70 ℃;

N,N-dimethyl-formamide; In diethyl ether; hexane; at -60 - 20 ℃;

Reference yield:

6-chloro-2-fluoro-3-lithioanisole + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 4-chloro-2-fluoro-3-methoxybenzaldehyde (1002344-97-9)

Guidance literature:

6-chloro-2-fluoro-3-lithioanisole; N,N-dimethyl-formamide; In tetrahydrofuran; hexane; at -75 - -50 ℃;

With hydrogenchloride; water; In tetrahydrofuran; hexane; at 20 ℃; for 2h;

upstream raw materials:

N,N-dimethyl-formamide

1-bromo-4-chloro-2-fluoro-3-methoxybenzene

1-chloro-3-fluoro-2-methoxybenzene

Downstream raw materials:

4-bromo-2-fluoro-3-methoxybenzaldehyde

Refernces

• 1、 -. "PROCESS FOR THE SELECTIVE DEPROTONATION AND FUNCTIONALIZATION OF 1-FLUORO-2-SUBSTITUTED-3-CHLOROBENZENES". Page/Page column 3. . Retrieved 2009/07/25.