1-Benzyl-2-methoxymethyl-aziridine-2-carboxylic acid benzyl-[(Z)-6-(4-methoxy-benzyloxy)-hex-3-enyl]-amide

Base Information

• Chemical Name: 1-Benzyl-2-methoxymethyl-aziridine-2-carboxylic acid benzyl-[(Z)-6-(4-methoxy-benzyloxy)-hex-3-enyl]-amide
• CAS No.: 220456-13-3
• Molecular Formula: C₃₃H₄₀N₂O₄
• Molecular Weight: 528.692

Synonyms:1-Benzyl-2-methoxymethyl-aziridine-2-carboxylic acid benzyl-[(Z)-6-(4-methoxy-benzyloxy)-hex-3-enyl]-amide

Chemical Property of 1-Benzyl-2-methoxymethyl-aziridine-2-carboxylic acid benzyl-[(Z)-6-(4-methoxy-benzyloxy)-hex-3-enyl]-amide

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Technology Process of 1-Benzyl-2-methoxymethyl-aziridine-2-carboxylic acid benzyl-[(Z)-6-(4-methoxy-benzyloxy)-hex-3-enyl]-amide

There total 2 articles about 1-Benzyl-2-methoxymethyl-aziridine-2-carboxylic acid benzyl-[(Z)-6-(4-methoxy-benzyloxy)-hex-3-enyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(Z)-6-(4-Methoxy-benzyloxy)-hex-3-enylamine → 1-Benzyl-2-methoxymethyl-aziridine-2-carboxylic acid benzyl-[(Z)-6-(4-methoxy-benzyloxy)-hex-3-enyl]-amide (220456-13-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) Me₃Al / 1) CH₂Cl₂, hexanes, 20 min, 2) CH₂Cl₂, hexanes, room temperature, overnight

2: 1) LiHMDS / 1) THF, 0 deg C, 15 min, 2) THF, 0 deg C -> room temperature, 2 h

With trimethylaluminum; lithium hexamethyldisilazane;

DOI:10.1021/jo981821d

Reference yield:

1-benzyl-2-methoxymethyl-aziridine-2-carboxylic acid methyl ester → 1-Benzyl-2-methoxymethyl-aziridine-2-carboxylic acid benzyl-[(Z)-6-(4-methoxy-benzyloxy)-hex-3-enyl]-amide (220456-13-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) Me₃Al / 1) CH₂Cl₂, hexanes, 20 min, 2) CH₂Cl₂, hexanes, room temperature, overnight

2: 1) LiHMDS / 1) THF, 0 deg C, 15 min, 2) THF, 0 deg C -> room temperature, 2 h

With trimethylaluminum; lithium hexamethyldisilazane;

DOI:10.1021/jo981821d

Reference yield: 59.0%

1-Benzyl-2-methoxymethyl-aziridine-2-carboxylic acid benzyl-[(Z)-6-(4-methoxy-benzyloxy)-hex-3-enyl]-amide (220456-13-3) → (3R,3aS,7aS)-1,6-Dibenzyl-3-[2-(4-methoxy-benzyloxy)-ethyl]-7a-methoxymethyl-octahydro-pyrrolo[2,3-c]pyridin-7-one

Guidance literature:

In 1,2-dichloro-benzene; at 320 ℃; for 2.5h;

DOI:10.1021/jo981821d

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