7-N-<4-O-(Methyl 5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-didedoxy-α-D-glycero-D-galacto-2-nonulopyranosylonate)phenyl>-9a-methoxymitosane

Base Information

• Chemical Name: 7-N-<4-O-(Methyl 5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-didedoxy-α-D-glycero-D-galacto-2-nonulopyranosylonate)phenyl>-9a-methoxymitosane
• CAS No.: 134136-43-9
• Molecular Formula: C₄₁H₄₉N₅O₁₈
• Molecular Weight: 899.863
• Mol file: 134136-43-9.mol

Synonyms:7-N-<4-O-(Methyl 5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-didedoxy-α-D-glycero-D-galacto-2-nonulopyranosylonate)phenyl>-9a-methoxymitosane

Chemical Property of 7-N-<4-O-(Methyl 5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-didedoxy-α-D-glycero-D-galacto-2-nonulopyranosylonate)phenyl>-9a-methoxymitosane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-N-<4-O-(Methyl 5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-didedoxy-α-D-glycero-D-galacto-2-nonulopyranosylonate)phenyl>-9a-methoxymitosane

There total 2 articles about 7-N-<4-O-(Methyl 5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-didedoxy-α-D-glycero-D-galacto-2-nonulopyranosylonate)phenyl>-9a-methoxymitosane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

mitomycin A (4055-39-4) + methyl (4-aminophenyl 5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-2-oxy-α-D-glycero-D-galacto-2-nonulopyranosid)onate (130087-26-2) → 7-N-<4-O-(Methyl 5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-didedoxy-α-D-glycero-D-galacto-2-nonulopyranosylonate)phenyl>-9a-methoxymitosane (134136-43-9)

Guidance literature:

In methanol; for 120h; Ambient temperature;

DOI:10.1248/cpb.39.255

Reference yield:

methyl (4-nitrophenyl 5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-2-oxy-α-D-glycero-D-galacto-2-nonulopyranosid)onate (59694-37-0) → 7-N-<4-O-(Methyl 5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-didedoxy-α-D-glycero-D-galacto-2-nonulopyranosylonate)phenyl>-9a-methoxymitosane (134136-43-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / hydrogen / PtO₂ / ethyl acetate / 2 h / Ambient temperature

2: 51 percent / methanol / 120 h / Ambient temperature

With hydrogen; platinum(IV) oxide; In methanol; ethyl acetate;

DOI:10.1248/cpb.39.255

Reference yield: 75.0%

7-N-<4-O-(Methyl 5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-didedoxy-α-D-glycero-D-galacto-2-nonulopyranosylonate)phenyl>-9a-methoxymitosane (134136-43-9) → 7-N-<4-O-(Methyl 5-acetamido-3,5-didedoxy-α-D-glycero-D-galacto-2-nonulopyranosylonate)phenyl>-9a-methoxymitosane (134136-44-0)

Guidance literature:

With methanol; sodium methylate; In methanol; for 0.416667h; Ambient temperature;

DOI:10.1248/cpb.39.255

upstream raw materials:

mitomycin A

methyl (4-aminophenyl 5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-2-oxy-α-D-glycero-D-galacto-2-nonulopyranosid)onate

methyl (4-nitrophenyl 5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-2-oxy-α-D-glycero-D-galacto-2-nonulopyranosid)onate

Downstream raw materials:

7-N-<4-O-(Methyl 5-acetamido-3,5-didedoxy-α-D-glycero-D-galacto-2-nonulopyranosylonate)phenyl>-9a-methoxymitosane