2-oxo-6,7-bis(hydroxymethyl)-5-(3,4-dichlorophenyl)-1,3-dihydropyrrolo<1,2-c>thiazole bis

Base Information

Chemical Name:2-oxo-6,7-bis(hydroxymethyl)-5-(3,4-dichlorophenyl)-1,3-dihydropyrrolo<1,2-c>thiazole bis
CAS No.:110271-32-4
Molecular Formula:C₂₂H₂₇Cl₂N₃O₅S
Molecular Weight:516.445
Hs Code.:

2-oxo-6,7-bis(hydroxymethyl)-5-(3,4-dichlorophenyl)-1,3-dihydropyrrolo<1,2-c>thiazole bis<N-(2-propyl)carbamate>

Synonyms:2-oxo-6,7-bis(hydroxymethyl)-5-(3,4-dichlorophenyl)-1,3-dihydropyrrolo<1,2-c>thiazole bis

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Chemical Property of 2-oxo-6,7-bis(hydroxymethyl)-5-(3,4-dichlorophenyl)-1,3-dihydropyrrolo<1,2-c>thiazole bis

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Technology Process of 2-oxo-6,7-bis(hydroxymethyl)-5-(3,4-dichlorophenyl)-1,3-dihydropyrrolo<1,2-c>thiazole bis

There total 5 articles about 2-oxo-6,7-bis(hydroxymethyl)-5-(3,4-dichlorophenyl)-1,3-dihydropyrrolo<1,2-c>thiazole bis which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.2%

: 110271-29-9
6,7-bis(hydroxymethyl)-5-(3,4-dichlorophenyl)-1,3-dihydropyrrolo<1,2-c>thiazole bis

: 110271-32-4
2-oxo-6,7-bis(hydroxymethyl)-5-(3,4-dichlorophenyl)-1,3-dihydropyrrolo<1,2-c>thiazole bis

Guidance literature:: With sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 25 ℃; for 0.25h;
DOI:10.1021/jm00394a030

Reference yield:

: 3024-72-4
3,4-dichlorobenzoyl chloride

: 110271-32-4
2-oxo-6,7-bis(hydroxymethyl)-5-(3,4-dichlorophenyl)-1,3-dihydropyrrolo<1,2-c>thiazole bis

Guidance literature:: Multi-step reaction with 5 steps

1: 98 percent / aq. 15percent NaOH / H₂O; diethyl ether / 16 h / 25 °C

2: 68 percent / acetic anhydride / 6 h / 120 °C

3: 75 percent / LiAlH₄ / CH₂Cl₂; diethyl ether / 1 h / Heating

4: 79 percent / dibutyltin diacetate / CH₂Cl₂ / 8 h / Ambient temperature

5: 53.2 percent / m-chloroperbenzoic acid, aq. 0.5 M NaHCO₃ / CH₂Cl₂ / 0.25 h / 25 °C

With sodium hydroxide; lithium aluminium tetrahydride; dibutyltin diacetate; acetic anhydride; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; In diethyl ether; dichloromethane; water;
DOI:10.1021/jm00394a030

Reference yield:

: 110271-24-4
N-(3,4-dichlorobenzoyl)thiazolidine-4-carboxylic acid

: 110271-32-4
2-oxo-6,7-bis(hydroxymethyl)-5-(3,4-dichlorophenyl)-1,3-dihydropyrrolo<1,2-c>thiazole bis

Guidance literature:: Multi-step reaction with 4 steps

1: 68 percent / acetic anhydride / 6 h / 120 °C

2: 75 percent / LiAlH₄ / CH₂Cl₂; diethyl ether / 1 h / Heating

3: 79 percent / dibutyltin diacetate / CH₂Cl₂ / 8 h / Ambient temperature

4: 53.2 percent / m-chloroperbenzoic acid, aq. 0.5 M NaHCO₃ / CH₂Cl₂ / 0.25 h / 25 °C

With lithium aluminium tetrahydride; dibutyltin diacetate; acetic anhydride; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; In diethyl ether; dichloromethane;
DOI:10.1021/jm00394a030