{5-methylsulfanyl-6-morpholin-4-yl-2-[4-(3-phenylureido)phenyl]pyrimidin-4-yl}acetic acid, sodium salt

Base Information

Chemical Name:{5-methylsulfanyl-6-morpholin-4-yl-2-[4-(3-phenylureido)phenyl]pyrimidin-4-yl}acetic acid, sodium salt
CAS No.:1313720-83-0
Molecular Formula:C₂₄H₂₄N₅O₄S*Na
Molecular Weight:501.541
Hs Code.:

Synonyms:{5-methylsulfanyl-6-morpholin-4-yl-2-[4-(3-phenylureido)phenyl]pyrimidin-4-yl}acetic acid, sodium salt

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Chemical Property of {5-methylsulfanyl-6-morpholin-4-yl-2-[4-(3-phenylureido)phenyl]pyrimidin-4-yl}acetic acid, sodium salt

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Technology Process of {5-methylsulfanyl-6-morpholin-4-yl-2-[4-(3-phenylureido)phenyl]pyrimidin-4-yl}acetic acid, sodium salt

There total 9 articles about {5-methylsulfanyl-6-morpholin-4-yl-2-[4-(3-phenylureido)phenyl]pyrimidin-4-yl}acetic acid, sodium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.2%

: 1313720-82-9
{5-methylsulfanyl-6-morpholin-4-yl-2-[4-(3-phenylureido)phenyl]pyrimidin-4-yl}acetic acid methyl ester

: 1313720-83-0
{5-methylsulfanyl-6-morpholin-4-yl-2-[4-(3-phenylureido)phenyl]pyrimidin-4-yl}acetic acid, sodium salt

Guidance literature:: With sodium hydroxide; In methanol; for 4h; Reflux;

Reference yield:

: 24795-76-4
2,4,6-trichloro-5-methylthio-pyrimidine

: 1313720-83-0
{5-methylsulfanyl-6-morpholin-4-yl-2-[4-(3-phenylureido)phenyl]pyrimidin-4-yl}acetic acid, sodium salt

Guidance literature:: Multi-step reaction with 8 steps

1: methanol / 0 - 20 °C

2: sodium hydride / N,N-dimethyl-formamide / 0 - 100 °C

3: hydrogenchloride / water; methanol / 24 h / 100 °C

4: trichlorophosphate / 4 h / 90 °C

5: tetrahydrofuran / 2 h / 20 °C

6: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 12 h / 90 °C / Inert atmosphere

7: dichloromethane; toluene / 16 h / 90 °C / Inert atmosphere

8: sodium hydroxide / methanol / 4 h / Reflux

With hydrogenchloride; sodium hydride; sodium carbonate; sodium hydroxide; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 56035-32-6
5-methylsulfanyl-pyrimidine-2,4,6-trione

: 1313720-83-0
{5-methylsulfanyl-6-morpholin-4-yl-2-[4-(3-phenylureido)phenyl]pyrimidin-4-yl}acetic acid, sodium salt

Guidance literature:: Multi-step reaction with 9 steps

1: trichlorophosphate; N,N-dimethyl-aniline / 24 h / Reflux

2: methanol / 0 - 20 °C

3: sodium hydride / N,N-dimethyl-formamide / 0 - 100 °C

4: hydrogenchloride / water; methanol / 24 h / 100 °C

5: trichlorophosphate / 4 h / 90 °C

6: tetrahydrofuran / 2 h / 20 °C

7: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 12 h / 90 °C / Inert atmosphere

8: dichloromethane; toluene / 16 h / 90 °C / Inert atmosphere

9: sodium hydroxide / methanol / 4 h / Reflux

With hydrogenchloride; sodium hydride; sodium carbonate; N,N-dimethyl-aniline; sodium hydroxide; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;