(9S,12S,15S)-15-tert-Butoxycarbonylamino-4-methoxy-12-(4-methoxy-benzyl)-19-nitro-11,14-dioxo-2-oxa-10,13-diaza-tricyclo[15.2.2.1^3,7]docosa-1⁽²⁰⁾,3,5,7⁽²²⁾,17⁽²¹⁾,18-hexaene-9-carboxylic acid methyl ester

Base Information

• Chemical Name: (9S,12S,15S)-15-tert-Butoxycarbonylamino-4-methoxy-12-(4-methoxy-benzyl)-19-nitro-11,14-dioxo-2-oxa-10,13-diaza-tricyclo[15.2.2.1^3,7]docosa-1⁽²⁰⁾,3,5,7⁽²²⁾,17⁽²¹⁾,18-hexaene-9-carboxylic acid methyl ester
• CAS No.: 291781-67-4
• Molecular Formula: C₃₅H₄₀N₄O₁₁
• Molecular Weight: 692.723

Synonyms:(9S,12S,15S)-15-tert-Butoxycarbonylamino-4-methoxy-12-(4-methoxy-benzyl)-19-nitro-11,14-dioxo-2-oxa-10,13-diaza-tricyclo[15.2.2.1^3,7]docosa-1⁽²⁰⁾,3,5,7⁽²²⁾,17⁽²¹⁾,18-hexaene-9-carboxylic acid methyl ester

Chemical Property of (9S,12S,15S)-15-tert-Butoxycarbonylamino-4-methoxy-12-(4-methoxy-benzyl)-19-nitro-11,14-dioxo-2-oxa-10,13-diaza-tricyclo[15.2.2.1^3,7]docosa-1⁽²⁰⁾,3,5,7⁽²²⁾,17⁽²¹⁾,18-hexaene-9-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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Useful:

Technology Process of (9S,12S,15S)-15-tert-Butoxycarbonylamino-4-methoxy-12-(4-methoxy-benzyl)-19-nitro-11,14-dioxo-2-oxa-10,13-diaza-tricyclo[15.2.2.1^3,7]docosa-1⁽²⁰⁾,3,5,7⁽²²⁾,17⁽²¹⁾,18-hexaene-9-carboxylic acid methyl ester

There total 8 articles about (9S,12S,15S)-15-tert-Butoxycarbonylamino-4-methoxy-12-(4-methoxy-benzyl)-19-nitro-11,14-dioxo-2-oxa-10,13-diaza-tricyclo[15.2.2.1^3,7]docosa-1⁽²⁰⁾,3,5,7⁽²²⁾,17⁽²¹⁾,18-hexaene-9-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(S)-2-[(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(4-fluoro-3-nitro-phenyl)-propionylamino]-3-(4-methoxy-phenyl)-propionylamino]-3-(3-hydroxy-4-methoxy-phenyl)-propionic acid methyl ester (291781-66-3) → (9S,12S,15S)-15-tert-Butoxycarbonylamino-4-methoxy-12-(4-methoxy-benzyl)-19-nitro-11,14-dioxo-2-oxa-10,13-diaza-tricyclo[15.2.2.13,7]docosa-1(20),3,5,7(22),17(21),18-hexaene-9-carboxylic acid methyl ester (291781-67-4)

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide; at 20 ℃; for 24h;

DOI:10.1016/S0040-4039(00)00695-X

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → (9S,12S,15S)-15-tert-Butoxycarbonylamino-4-methoxy-12-(4-methoxy-benzyl)-19-nitro-11,14-dioxo-2-oxa-10,13-diaza-tricyclo[15.2.2.13,7]docosa-1(20),3,5,7(22),17(21),18-hexaene-9-carboxylic acid methyl ester (291781-67-4)

Guidance literature:

Multi-step reaction with 2 steps

2: 99 percent / K₂CO₃ / dimethylsulfoxide / 24 h / 20 °C

With potassium carbonate; In dimethyl sulfoxide; 1: Acylation / 2: Cyclization;

DOI:10.1016/S0040-4039(00)00695-X

Reference yield:

methyl (S)-2-amino-3-(4-methoxyphenyl)propionate (17355-19-0) → (9S,12S,15S)-15-tert-Butoxycarbonylamino-4-methoxy-12-(4-methoxy-benzyl)-19-nitro-11,14-dioxo-2-oxa-10,13-diaza-tricyclo[15.2.2.13,7]docosa-1(20),3,5,7(22),17(21),18-hexaene-9-carboxylic acid methyl ester (291781-67-4)

Guidance literature:

Multi-step reaction with 6 steps

1: 85 percent / EDC; HOBt

2: LiOH / tetrahydrofuran; H₂O

3: EDC; HOBt

4: BCl₃

6: 99 percent / K₂CO₃ / dimethylsulfoxide / 24 h / 20 °C

With lithium hydroxide; boron trichloride; potassium carbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; water; dimethyl sulfoxide; 1: Dehydration / 2: Hydrolysis / 3: Condensation / 4: dealkyation / 5: Acylation / 6: Cyclization;

DOI:10.1016/S0040-4039(00)00695-X

upstream raw materials:

(S)-2-[(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(4-fluoro-3-nitro-phenyl)-propionylamino]-3-(4-methoxy-phenyl)-propionylamino]-3-(3-hydroxy-4-methoxy-phenyl)-propionic acid methyl ester

di-tert-butyl dicarbonate

methyl (S)-2-amino-3-(4-methoxyphenyl)propionate

(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(4-fluoro-3-nitro-phenyl)-propionylamino]-3-(4-methoxy-phenyl)-propionic acid methyl ester

Downstream raw materials:

(9S,12S,15S)-15-Acetylamino-19-amino-4-methoxy-12-(4-methoxy-benzyl)-11,14-dioxo-2-oxa-10,13-diaza-tricyclo[15.2.2.1^3,7]docosa-1⁽²⁰⁾,3,5,7⁽²²⁾,17⁽²¹⁾,18-hexaene-9-carboxylic acid methyl ester

(9S,12S,15S)-15-Acetylamino-4-methoxy-12-(4-methoxy-benzyl)-19-nitro-11,14-dioxo-2-oxa-10,13-diaza-tricyclo[15.2.2.1^3,7]docosa-1⁽²⁰⁾,3,5,7⁽²²⁾,17⁽²¹⁾,18-hexaene-9-carboxylic acid methyl ester

(9S,12S,15S)-15-Acetylamino-4-methoxy-12-(4-methoxy-benzyl)-11,14-dioxo-2-oxa-10,13-diaza-tricyclo[15.2.2.1^3,7]docosa-1⁽²⁰⁾,3,5,7⁽²²⁾,17⁽²¹⁾,18-hexaene-9-carboxylic acid methyl ester

(9S,12S,15S)-15-Amino-4-methoxy-12-(4-methoxy-benzyl)-19-nitro-11,14-dioxo-2-oxa-10,13-diaza-tricyclo[15.2.2.1^3,7]docosa-1⁽²⁰⁾,3,5,7⁽²²⁾,17⁽²¹⁾,18-hexaene-9-carboxylic acid methyl ester

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