Technology Process of (1R,2R)-2-(3,5-dimethyl-1H-pyrazol-1-yl)-1,2-bis(4-fluorophenyl)ethanol
There total 1 articles about (1R,2R)-2-(3,5-dimethyl-1H-pyrazol-1-yl)-1,2-bis(4-fluorophenyl)ethanol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
3,5-dimethyl-1H-pyrazole;
With
C35H48N4O4; scandium tris(trifluoromethanesulfonate);
In
dichloromethane;
at 35 ℃;
for 0.0833333h;
Molecular sieve;
Inert atmosphere;
(2R,3S)-2,3-bis(4-fluorophenyl)oxirane;
In
dichloromethane;
at 35 ℃;
for 48h;
optical yield given as %ee;
enantioselective reaction;
Inert atmosphere;
Molecular sieve;
DOI:10.1002/chem.201103792