(R)-6-((R)-1-hydroxy-2-phenylethyl)piperidin-2-one

Base Information

Chemical Name:(R)-6-((R)-1-hydroxy-2-phenylethyl)piperidin-2-one
CAS No.:1399282-35-9
Molecular Formula:C₁₃H₁₇NO₂
Molecular Weight:219.283
Hs Code.:

Synonyms:(R)-6-((R)-1-hydroxy-2-phenylethyl)piperidin-2-one

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Chemical Property of (R)-6-((R)-1-hydroxy-2-phenylethyl)piperidin-2-one

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Technology Process of (R)-6-((R)-1-hydroxy-2-phenylethyl)piperidin-2-one

There total 6 articles about (R)-6-((R)-1-hydroxy-2-phenylethyl)piperidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1399282-23-5
(R)-N,N-dibenzyl-1-((S)-2,2-dimethyl-1,3-doxolan-4-yl)-3-(trimethylsilyl)prop-2-yn-1-amine

: 1399282-35-9
(R)-6-((R)-1-hydroxy-2-phenylethyl)piperidin-2-one

Guidance literature:: Multi-step reaction with 7 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

2: copper(l) iodide / acetonitrile / 12 h / 20 °C / Inert atmosphere

3: Pd(OH)2/C; hydrogen / ethanol / 24 h / 20 °C / 5171.62 Torr / Inert atmosphere

4: sodium ethanolate / ethanol / 2 h / Inert atmosphere; Reflux

5: hydrogenchloride / ethanol / 2 h / 20 °C / Inert atmosphere

6: triphenylphosphine; di-isopropyl azodicarboxylate / chloroform / 24 h / Inert atmosphere; Reflux

7: copper(l) iodide / tetrahydrofuran; pentane; dibutyl ether / 2 h / -35 °C / Inert atmosphere

With hydrogenchloride; copper(l) iodide; di-isopropyl azodicarboxylate; Pd(OH)2/C; tetrabutyl ammonium fluoride; hydrogen; sodium ethanolate; triphenylphosphine; In tetrahydrofuran; ethanol; chloroform; dibutyl ether; acetonitrile; pentane; 6: |Mitsunobu Displacement;
DOI:10.1039/c2ob26007g

Reference yield:

: 1399282-10-0
(R)-N,N-dibenzyl-1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-prop-2-yn-1-amine

: 1399282-35-9
(R)-6-((R)-1-hydroxy-2-phenylethyl)piperidin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: copper(l) iodide / acetonitrile / 12 h / 20 °C / Inert atmosphere

2: Pd(OH)2/C; hydrogen / ethanol / 24 h / 20 °C / 5171.62 Torr / Inert atmosphere

3: sodium ethanolate / ethanol / 2 h / Inert atmosphere; Reflux

4: hydrogenchloride / ethanol / 2 h / 20 °C / Inert atmosphere

5: triphenylphosphine; di-isopropyl azodicarboxylate / chloroform / 24 h / Inert atmosphere; Reflux

6: copper(l) iodide / tetrahydrofuran; pentane; dibutyl ether / 2 h / -35 °C / Inert atmosphere

With hydrogenchloride; copper(l) iodide; di-isopropyl azodicarboxylate; Pd(OH)2/C; hydrogen; sodium ethanolate; triphenylphosphine; In tetrahydrofuran; ethanol; chloroform; dibutyl ether; acetonitrile; pentane; 5: |Mitsunobu Displacement;
DOI:10.1039/c2ob26007g

Reference yield:

: 1399282-24-6
(R)-ethyl 5-(dibenzylamino)-5-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)pent-3-ynoate

: 1399282-35-9
(R)-6-((R)-1-hydroxy-2-phenylethyl)piperidin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: Pd(OH)2/C; hydrogen / ethanol / 24 h / 20 °C / 5171.62 Torr / Inert atmosphere

2: sodium ethanolate / ethanol / 2 h / Inert atmosphere; Reflux

3: hydrogenchloride / ethanol / 2 h / 20 °C / Inert atmosphere

4: triphenylphosphine; di-isopropyl azodicarboxylate / chloroform / 24 h / Inert atmosphere; Reflux

5: copper(l) iodide / tetrahydrofuran; pentane; dibutyl ether / 2 h / -35 °C / Inert atmosphere

With hydrogenchloride; copper(l) iodide; di-isopropyl azodicarboxylate; Pd(OH)2/C; hydrogen; sodium ethanolate; triphenylphosphine; In tetrahydrofuran; ethanol; chloroform; dibutyl ether; pentane; 4: |Mitsunobu Displacement;
DOI:10.1039/c2ob26007g