benzyl (S)-3-{4-[9-(tetrahydropyran-2-yl)purin-6-yl]phenyl}-2-[(benzyloxycarbonyl)amino]propanoate

Base Information

Chemical Name:benzyl (S)-3-{4-[9-(tetrahydropyran-2-yl)purin-6-yl]phenyl}-2-[(benzyloxycarbonyl)amino]propanoate
CAS No.:868071-63-0
Molecular Formula:C₃₄H₃₃N₅O₅
Molecular Weight:591.667
Hs Code.:

Synonyms:benzyl (S)-3-{4-[9-(tetrahydropyran-2-yl)purin-6-yl]phenyl}-2-[(benzyloxycarbonyl)amino]propanoate

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Chemical Property of benzyl (S)-3-{4-[9-(tetrahydropyran-2-yl)purin-6-yl]phenyl}-2-[(benzyloxycarbonyl)amino]propanoate

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Technology Process of benzyl (S)-3-{4-[9-(tetrahydropyran-2-yl)purin-6-yl]phenyl}-2-[(benzyloxycarbonyl)amino]propanoate

There total 1 articles about benzyl (S)-3-{4-[9-(tetrahydropyran-2-yl)purin-6-yl]phenyl}-2-[(benzyloxycarbonyl)amino]propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: benzyl (S)-2-[(benzyloxycarbonyl)amino]-3-[4-(trimethylstannyl)phenyl]propionate

: 71819-06-2
6-iodo-9-(tetrahydro-2H-pyran-2-yl)-9H-purine

: 868071-63-0
benzyl (S)-3-{4-[9-(tetrahydropyran-2-yl)purin-6-yl]phenyl}-2-[(benzyloxycarbonyl)amino]propanoate

Guidance literature:: With copper(l) iodide; triphenyl-arsane; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In N,N-dimethyl-formamide; at 70 ℃; for 4h;
DOI:10.1021/jo051110x

Reference yield: 98.0%

: 868071-63-0
benzyl (S)-3-{4-[9-(tetrahydropyran-2-yl)purin-6-yl]phenyl}-2-[(benzyloxycarbonyl)amino]propanoate

: 868071-74-3
benzyl (S)-3-{4-[9H-purin-6-yl]phenyl}-2-[(benzyloxycarbonyl)amino]propanoate

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1.25h;
DOI:10.1021/jo051110x

Reference yield:

: 868071-63-0
benzyl (S)-3-{4-[9-(tetrahydropyran-2-yl)purin-6-yl]phenyl}-2-[(benzyloxycarbonyl)amino]propanoate

: (S)-3-{4-[9H-purin-6-yl]phenyl}-2-aminopropanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / CF₃CO₂H / CH₂Cl₂ / 1.25 h / 20 °C

2: H₂; HCl / Pd/C / dimethylformamide; H₂O / 10 h

With hydrogenchloride; hydrogen; trifluoroacetic acid; palladium on activated charcoal; In dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jo051110x