3-(2-((3-chloro-4-isopropoxyphenyl)amino)-1-(4-chlorobenzyl)-6-oxo-1,6-dihydropyrimidin-5-yl)propanoic acid

Base Information

Chemical Name:3-(2-((3-chloro-4-isopropoxyphenyl)amino)-1-(4-chlorobenzyl)-6-oxo-1,6-dihydropyrimidin-5-yl)propanoic acid
CAS No.:1359815-84-1
Molecular Formula:C₂₃H₂₃Cl₂N₃O₄
Molecular Weight:476.359
Hs Code.:

Synonyms:3-(2-((3-chloro-4-isopropoxyphenyl)amino)-1-(4-chlorobenzyl)-6-oxo-1,6-dihydropyrimidin-5-yl)propanoic acid

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Chemical Property of 3-(2-((3-chloro-4-isopropoxyphenyl)amino)-1-(4-chlorobenzyl)-6-oxo-1,6-dihydropyrimidin-5-yl)propanoic acid

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Technology Process of 3-(2-((3-chloro-4-isopropoxyphenyl)amino)-1-(4-chlorobenzyl)-6-oxo-1,6-dihydropyrimidin-5-yl)propanoic acid

There total 7 articles about 3-(2-((3-chloro-4-isopropoxyphenyl)amino)-1-(4-chlorobenzyl)-6-oxo-1,6-dihydropyrimidin-5-yl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 2-(3-chloro-4-isopropoxyphenylamino)-3-(4-chlorobenzyl)-5-(2-ethoxycarbonylethenyl) pyrimidine-4(3H)-one

: 1359815-84-1
3-(2-((3-chloro-4-isopropoxyphenyl)amino)-1-(4-chlorobenzyl)-6-oxo-1,6-dihydropyrimidin-5-yl)propanoic acid

Guidance literature:: 2-(3-chloro-4-isopropoxyphenylamino)-3-(4-chlorobenzyl)-5-(2-ethoxycarbonylethenyl) pyrimidine-4(3H)-one; With platinum on carbon; hydrogen; In chloroform; N,N-dimethyl-formamide;

With water; lithium hydroxide; In ethanol; at 20 ℃; for 4h;

Reference yield: 35.0%

: 2-(3-chloro-4-isopropoxyphenylamino)-3-(4-chlorobenzyl)-5-(2-hydroxycarbonylethenyl) pyrimidine-4(3H)-one

: 1359815-84-1
3-(2-((3-chloro-4-isopropoxyphenyl)amino)-1-(4-chlorobenzyl)-6-oxo-1,6-dihydropyrimidin-5-yl)propanoic acid

Guidance literature:: With platinum on activated charcoal; hydrogen; In chloroform; N,N-dimethyl-formamide; at 20 ℃; for 4h;
DOI:10.1016/j.bmcl.2021.127833

Reference yield:

: 3-(4-chlorobenzyl)-5-(2-ethoxycarbonylethenyl)-2-(methylthio) pyrimidine-4(3H)-one

: 1359815-84-1
3-(2-((3-chloro-4-isopropoxyphenyl)amino)-1-(4-chlorobenzyl)-6-oxo-1,6-dihydropyrimidin-5-yl)propanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetic acid / tert-butyl alcohol / Reflux

2.1: hydrogen; platinum on carbon / N,N-dimethyl-formamide; chloroform

2.2: 4 h / 20 °C

With platinum on carbon; hydrogen; acetic acid; In chloroform; N,N-dimethyl-formamide; tert-butyl alcohol;