(R)-N-(3-oxo-1-phenyl-3-(2-(piperidin-1-ylmethyl)-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)propyl)naphthalene-2-sulfonamide

Base Information

• Chemical Name: (R)-N-(3-oxo-1-phenyl-3-(2-(piperidin-1-ylmethyl)-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)propyl)naphthalene-2-sulfonamide
• CAS No.: 1190970-05-8
• Molecular Formula: C₃₂H₃₅N₃O₃S₂
• Molecular Weight: 573.78
• Mol file: 1190970-05-8.mol

Synonyms:(R)-N-(3-oxo-1-phenyl-3-(2-(piperidin-1-ylmethyl)-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)propyl)naphthalene-2-sulfonamide

Chemical Property of (R)-N-(3-oxo-1-phenyl-3-(2-(piperidin-1-ylmethyl)-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)propyl)naphthalene-2-sulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-N-(3-oxo-1-phenyl-3-(2-(piperidin-1-ylmethyl)-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)propyl)naphthalene-2-sulfonamide

There total 10 articles about (R)-N-(3-oxo-1-phenyl-3-(2-(piperidin-1-ylmethyl)-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)propyl)naphthalene-2-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

(R)-3-(naphthalene-2-sulfonamido)-3-phenylpropanoic acid (193634-01-4) + 2-(piperidin-1-ylmethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine (1190971-13-1) → (R)-N-(3-oxo-1-phenyl-3-(2-(piperidin-1-ylmethyl)-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)propyl)naphthalene-2-sulfonamide (1190970-05-8)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; at 0 - 20 ℃;

Reference yield:

5-tert-butoxycarbonyl-2-hydroxymethyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridine (165947-56-8) → (R)-N-(3-oxo-1-phenyl-3-(2-(piperidin-1-ylmethyl)-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)propyl)naphthalene-2-sulfonamide (1190970-05-8)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium hypochlorite; sodium hydrogencarbonate / 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / dichloromethane; water / 0 - 20 °C

2: sodium tris(acetoxy)borohydride; acetic acid / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere

3: trifluoroacetic acid / dichloromethane / 4 h / 20 °C

4: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 0 - 20 °C

With sodium hypochlorite; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; In tetrahydrofuran; dichloromethane; water;

Reference yield:

benzyl 4-chloro-3-formyl-5,6-dihydropyridine-1(2H)-carboxylate (1190971-25-5) → (R)-N-(3-oxo-1-phenyl-3-(2-(piperidin-1-ylmethyl)-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)propyl)naphthalene-2-sulfonamide (1190970-05-8)

Guidance literature:

Multi-step reaction with 7 steps

1.1: triethylamine / dichloromethane / 0 - 20 °C

2.1: hydrogen; triethylamine / palladium 10% on activated carbon / ethanol / 4654.46 Torr

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C

3.2: Saturated solution

4.1: sodium hypochlorite; sodium hydrogencarbonate / 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / dichloromethane; water / 0 - 20 °C

5.1: sodium tris(acetoxy)borohydride; acetic acid / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere

6.1: trifluoroacetic acid / dichloromethane / 4 h / 20 °C

7.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 0 - 20 °C

With sodium hypochlorite; lithium aluminium tetrahydride; hydrogen; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; water;

upstream raw materials:

(R)-3-(naphthalene-2-sulfonamido)-3-phenylpropanoic acid

2-(piperidin-1-ylmethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

tert-butyl 2-(formyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-carboxylate

5-tert-butoxycarbonyl-2-hydroxymethyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridine