5'-O-(4,4'-dimethoxytrityl)-2,8--8-amino-2'-deoxyguanosine

Base Information

• Chemical Name: 5'-O-(4,4'-dimethoxytrityl)-2,8--8-amino-2'-deoxyguanosine
• CAS No.: 166092-90-6
• Molecular Formula: C₃₇H₄₂N₈O₆
• Molecular Weight: 694.79

Synonyms:5'-O-(4,4'-dimethoxytrityl)-2,8--8-amino-2'-deoxyguanosine

Chemical Property of 5'-O-(4,4'-dimethoxytrityl)-2,8--8-amino-2'-deoxyguanosine

Chemical Property:

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Technology Process of 5'-O-(4,4'-dimethoxytrityl)-2,8--8-amino-2'-deoxyguanosine

There total 2 articles about 5'-O-(4,4'-dimethoxytrityl)-2,8--8-amino-2'-deoxyguanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

4,4'-dimethoxytrityl chloride (40615-36-9) + N2,N8-bis<(dimethylamino)methylene>-8-amino-2'-deoxyguanosine (166092-89-3) → 5'-O-(4,4'-dimethoxytrityl)-2,8--8-amino-2'-deoxyguanosine (166092-90-6)

Guidance literature:

In pyridine; for 3.5h; Ambient temperature;

DOI:10.1002/jhet.5570310441

Reference yield:

8-amino-2'-deoxyguanosine (13389-04-3) → 5'-O-(4,4'-dimethoxytrityl)-2,8--8-amino-2'-deoxyguanosine (166092-90-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / dimethylformamide / 36 h / Ambient temperature

2: 74 percent / pyridine / 3.5 h / Ambient temperature

In pyridine; N,N-dimethyl-formamide;

DOI:10.1002/jhet.5570310441

Reference yield: 79.0%

2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine (124482-92-4,89992-70-1) + 5'-O-(4,4'-dimethoxytrityl)-2,8--8-amino-2'-deoxyguanosine (166092-90-6) → 3'-O-(P-β-cyanoethoxy-N,N-diisopropylaminophosphinyl)-5'-O-(4,4'-dimethoxytrityl)-2,8--8-amino-2'-deoxyguanosine

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 0.583333h; Ambient temperature;

DOI:10.1002/jhet.5570310441

upstream raw materials:

4,4'-dimethoxytrityl chloride

N²,N⁸-bis<(dimethylamino)methylene>-8-amino-2'-deoxyguanosine

8-amino-2'-deoxyguanosine

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