2-Amino-6-[1-(3-fluoro-phenyl)-1-hydroxy-but-3-ynyl]-benzoimidazole-1-sulfonic acid dimethylamide

Base Information

Chemical Name:2-Amino-6-[1-(3-fluoro-phenyl)-1-hydroxy-but-3-ynyl]-benzoimidazole-1-sulfonic acid dimethylamide
CAS No.:186094-42-8
Molecular Formula:C₁₉H₁₉FN₄O₃S
Molecular Weight:402.449
Hs Code.:

Synonyms:2-Amino-6-[1-(3-fluoro-phenyl)-1-hydroxy-but-3-ynyl]-benzoimidazole-1-sulfonic acid dimethylamide

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Chemical Property of 2-Amino-6-[1-(3-fluoro-phenyl)-1-hydroxy-but-3-ynyl]-benzoimidazole-1-sulfonic acid dimethylamide

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Technology Process of 2-Amino-6-[1-(3-fluoro-phenyl)-1-hydroxy-but-3-ynyl]-benzoimidazole-1-sulfonic acid dimethylamide

There total 7 articles about 2-Amino-6-[1-(3-fluoro-phenyl)-1-hydroxy-but-3-ynyl]-benzoimidazole-1-sulfonic acid dimethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 501-00-8
3-fluorophenylacetonitrile

: 186094-42-8
2-Amino-6-[1-(3-fluoro-phenyl)-1-hydroxy-but-3-ynyl]-benzoimidazole-1-sulfonic acid dimethylamide

Guidance literature:: Multi-step reaction with 6 steps

1: t-BuOK / dimethylformamide / 4 h / Ambient temperature

2: 30percent aq. H₂O₂ / dimethylformamide / 0 - 20 °C

3: 94 percent / H₂ / Raney nickel / tetrahydrofuran / 12 h / 3102.9 Torr

4: pyridine / CH₂Cl₂ / 5 h / Ambient temperature

5: 2N aq. NaOH / propan-2-ol; acetonitrile / Ambient temperature

6: tetrahydrofuran; diethyl ether; toluene / 2 h

With pyridine; sodium hydroxide; potassium tert-butylate; hydrogen; dihydrogen peroxide; nickel; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; toluene; acetonitrile;
DOI:10.1021/jm970423k

Reference yield:

: 1635-61-6
5-chloro-2-nitroaniline

: 186094-42-8
2-Amino-6-[1-(3-fluoro-phenyl)-1-hydroxy-but-3-ynyl]-benzoimidazole-1-sulfonic acid dimethylamide

Guidance literature:: Multi-step reaction with 6 steps

1: t-BuOK / dimethylformamide / 4 h / Ambient temperature

2: 30percent aq. H₂O₂ / dimethylformamide / 0 - 20 °C

3: 94 percent / H₂ / Raney nickel / tetrahydrofuran / 12 h / 3102.9 Torr

4: pyridine / CH₂Cl₂ / 5 h / Ambient temperature

5: 2N aq. NaOH / propan-2-ol; acetonitrile / Ambient temperature

6: tetrahydrofuran; diethyl ether; toluene / 2 h

With pyridine; sodium hydroxide; potassium tert-butylate; hydrogen; dihydrogen peroxide; nickel; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; toluene; acetonitrile;
DOI:10.1021/jm970423k

Reference yield:

: 1027585-85-8
3-amino-4-nitro-3'-fluorobenzophenone

: 186094-42-8
2-Amino-6-[1-(3-fluoro-phenyl)-1-hydroxy-but-3-ynyl]-benzoimidazole-1-sulfonic acid dimethylamide

Guidance literature:: Multi-step reaction with 4 steps

1: 94 percent / H₂ / Raney nickel / tetrahydrofuran / 12 h / 3102.9 Torr

2: pyridine / CH₂Cl₂ / 5 h / Ambient temperature

3: 2N aq. NaOH / propan-2-ol; acetonitrile / Ambient temperature

4: tetrahydrofuran; diethyl ether; toluene / 2 h

With pyridine; sodium hydroxide; hydrogen; nickel; In tetrahydrofuran; diethyl ether; dichloromethane; isopropyl alcohol; toluene; acetonitrile;
DOI:10.1021/jm970423k