2-[(R)-2-((S)-5-tert-Butoxycarbonyl-3-methyl-2-oxo-imidazolidin-1-yl)-1-methyl-2-oxo-ethyl]-malonic acid dibenzyl ester

Base Information

Chemical Name:2-[(R)-2-((S)-5-tert-Butoxycarbonyl-3-methyl-2-oxo-imidazolidin-1-yl)-1-methyl-2-oxo-ethyl]-malonic acid dibenzyl ester
CAS No.:170704-11-7
Molecular Formula:C₂₉H₃₄N₂O₈
Molecular Weight:538.598
Hs Code.:

Synonyms:2-[(R)-2-((S)-5-tert-Butoxycarbonyl-3-methyl-2-oxo-imidazolidin-1-yl)-1-methyl-2-oxo-ethyl]-malonic acid dibenzyl ester

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Chemical Property of 2-[(R)-2-((S)-5-tert-Butoxycarbonyl-3-methyl-2-oxo-imidazolidin-1-yl)-1-methyl-2-oxo-ethyl]-malonic acid dibenzyl ester

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Technology Process of 2-[(R)-2-((S)-5-tert-Butoxycarbonyl-3-methyl-2-oxo-imidazolidin-1-yl)-1-methyl-2-oxo-ethyl]-malonic acid dibenzyl ester

There total 1 articles about 2-[(R)-2-((S)-5-tert-Butoxycarbonyl-3-methyl-2-oxo-imidazolidin-1-yl)-1-methyl-2-oxo-ethyl]-malonic acid dibenzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 15014-25-2
malonic acid dibenzyl ester

: 195828-75-2
tert.-butyl (4S)-1-methyl-3-(2-bromopropionyl)-2-oxo-imidazolidine-4-carboxylate

: 170704-11-7
2-[(R)-2-((S)-5-tert-Butoxycarbonyl-3-methyl-2-oxo-imidazolidin-1-yl)-1-methyl-2-oxo-ethyl]-malonic acid dibenzyl ester

: 2-[(S)-2-((S)-5-tert-Butoxycarbonyl-3-methyl-2-oxo-imidazolidin-1-yl)-1-methyl-2-oxo-ethyl]-malonic acid dibenzyl ester

Guidance literature:: With sodium hydride; In N,N,N,N,N,N-hexamethylphosphoric triamide; for 12h; Yield given. Yields of byproduct given; Ambient temperature;
DOI:10.1016/0040-4039(95)01236-B

Reference yield:

: 170704-11-7
2-[(R)-2-((S)-5-tert-Butoxycarbonyl-3-methyl-2-oxo-imidazolidin-1-yl)-1-methyl-2-oxo-ethyl]-malonic acid dibenzyl ester

: 185836-75-3
(R)-3-tert-butyloxycarbonyl-2-methylpropanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 97 percent / H₂ / Pd/C / methanol / 3 h / Ambient temperature

2: 86 percent / dimethylsulfoxide / 1 h / 100 °C

3: 91 percent / H₂SO₄ / CH₂Cl₂ / 12 h / Ambient temperature

4: 79 percent / LiOH*H₂O / tetrahydrofuran; H₂O / 3 h / Ambient temperature

With lithium hydroxide; sulfuric acid; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide;
DOI:10.1021/jo970484q

Reference yield:

: 170704-11-7
2-[(R)-2-((S)-5-tert-Butoxycarbonyl-3-methyl-2-oxo-imidazolidin-1-yl)-1-methyl-2-oxo-ethyl]-malonic acid dibenzyl ester

: 195829-01-7
(S)-3-((R)-3-Benzyloxycarbonylamino-2-methyl-propionyl)-1-methyl-2-oxo-imidazolidine-4-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / H₂ / Pd/C / methanol / 3 h / Ambient temperature

2: 86 percent / dimethylsulfoxide / 1 h / 100 °C

3: 1.) DPPA, Et₃N / 1.) toluene, 80 deg C, 1 h, 2.) 80 deg C, 12 h

With diphenyl-phosphinic acid; hydrogen; triethylamine; palladium on activated charcoal; In methanol; dimethyl sulfoxide;
DOI:10.1021/jo970484q