Technology Process of Cyclopropanepropanoic acid, -alpha--amino-2-methylene-, methyl ester
There total 19 articles about Cyclopropanepropanoic acid, -alpha--amino-2-methylene-, methyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: pyridine, p-toluenesulfonyl chloride / CCl4; diethyl ether / 21 h / Ambient temperature; 1.) 0 deg C
2: 74 percent / n-BuLi / tetrahydrofuran; hexane / -78 deg C, 2 h 25 min, then room temp., 2 h 25 min
3: 0.25M HCl / H2O / 70 h / Ambient temperature
With
pyridine; hydrogenchloride; n-butyllithium; p-toluenesulfonyl chloride;
In
tetrahydrofuran; tetrachloromethane; diethyl ether; hexane; water;
DOI:10.1016/S0040-4020(01)89313-3
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 65 percent / pyridine, p-toluenesulfonyl chloride / CCl4; diethyl ether / 21 h / Ambient temperature; 1.) 0 deg C
2: 90 percent / n-BuLi / tetrahydrofuran; hexane / -78 deg C, 2 h 25 min, then room temp., 2 h 25 min
3: 0.25M HCl / H2O / 70 h / Ambient temperature
With
pyridine; hydrogenchloride; n-butyllithium; p-toluenesulfonyl chloride;
In
tetrahydrofuran; tetrachloromethane; diethyl ether; hexane; water;
DOI:10.1016/S0040-4020(01)89313-3