(S)-2-tert-butoxycarbonylamino-4-[5-(4-chloro-3-methanesulfonyl-phenyl)-4-methyI-thiazol-2-ylcarbamoyl]-butyric acid cyclopentyl ester

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Chemical Name:(S)-2-tert-butoxycarbonylamino-4-[5-(4-chloro-3-methanesulfonyl-phenyl)-4-methyI-thiazol-2-ylcarbamoyl]-butyric acid cyclopentyl ester
CAS No.:914382-90-4
Molecular Formula:C₂₆H₃₄ClN₃O₇S₂
Molecular Weight:600.157
Hs Code.:

Synonyms:(S)-2-tert-butoxycarbonylamino-4-[5-(4-chloro-3-methanesulfonyl-phenyl)-4-methyI-thiazol-2-ylcarbamoyl]-butyric acid cyclopentyl ester

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Chemical Property of (S)-2-tert-butoxycarbonylamino-4-[5-(4-chloro-3-methanesulfonyl-phenyl)-4-methyI-thiazol-2-ylcarbamoyl]-butyric acid cyclopentyl ester

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Technology Process of (S)-2-tert-butoxycarbonylamino-4-[5-(4-chloro-3-methanesulfonyl-phenyl)-4-methyI-thiazol-2-ylcarbamoyl]-butyric acid cyclopentyl ester

There total 3 articles about (S)-2-tert-butoxycarbonylamino-4-[5-(4-chloro-3-methanesulfonyl-phenyl)-4-methyI-thiazol-2-ylcarbamoyl]-butyric acid cyclopentyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 593959-38-7
5-[4-chloro-3-(methylsulfonyl)phenyl]-4-methyl-1,3-thiazol-2-amine

: 914382-67-5
(4S)-4-[(tert-butoxycarbonyl)amino]-5-(cycIopentyloxy)-5-oxopentanoic acid

: 914382-90-4
(S)-2-tert-butoxycarbonylamino-4-[5-(4-chloro-3-methanesulfonyl-phenyl)-4-methyI-thiazol-2-ylcarbamoyl]-butyric acid cyclopentyl ester

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

Reference yield:

: 219623-96-8
(S)-2-tert-butoxycarbonylamino-pentanedioic acid 5-benzyl ester 1-cyclopentyl ester

: 914382-90-4
(S)-2-tert-butoxycarbonylamino-4-[5-(4-chloro-3-methanesulfonyl-phenyl)-4-methyI-thiazol-2-ylcarbamoyl]-butyric acid cyclopentyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogen / palladium 10% on activated carbon / ethanol / 4 h / 20 °C

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C

2.2: 18 h / 20 °C

With hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium 10% on activated carbon; In ethanol; N,N-dimethyl-formamide;

Reference yield:

: 13574-13-5
Boc-Glu(OBzl)-OH

: 914382-90-4
(S)-2-tert-butoxycarbonylamino-4-[5-(4-chloro-3-methanesulfonyl-phenyl)-4-methyI-thiazol-2-ylcarbamoyl]-butyric acid cyclopentyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane; N,N-dimethyl-formamide / 0 - 20 °C

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 4 h / 20 °C

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C

3.2: 18 h / 20 °C

With dmap; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium 10% on activated carbon; In ethanol; dichloromethane; N,N-dimethyl-formamide;